Observational studyRevista do Instituto de Medicina Tropical de Sao Paulo2016
PREVALENCE OF BACTERIAL RESISTANCE IN HOSPITALIZED CIRRHOTIC PATIENTS IN SOUTHERN BRAZIL: A NEW CHALLENGE.
Observational study in Revista do Instituto de Medicina Tropical de Sao Paulo, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Drug-resistant bacterial infections in end-stage liver disease: immune imbalance and intervention advances.Frontiers in immunology · 2026Review
- Understanding the Utility of Automation for Diagnosing Spontaneous Bacterial Peritonitis and Its Variants.Cureus · 2025Article
- Impact of multidrug resistance on the management of bacterial infections in cirrhosis.World journal of clinical cases · 2023Review
- Albumin administration in patients with cirrhosis: Current role and novel perspectives.World journal of gastroenterology · 2022Review
- Treatment of Hospital-Acquired Infections in Patients with Cirrhosis - New Challenges.Infection and drug resistance · 2022Article
- Spontaneous Bacterial Peritonitis among Cirrhotic Patients: Prevalence, Clinical Characteristics, and Outcomes.Journal of clinical medicine · 2021Article
- Bacterial Infections in Cirrhotic Patients in a Tertiary Care Hospital.Journal of clinical and translational hepatology · 2021Article
- High Prevalence of Multidrug Resistant Bacteria in Cirrhotic Patients with Spontaneous Bacterial Peritonitis: Is It Time to Change the Standard Antimicrobial Approach?Canadian journal of gastroenterology & hepatology · 2019Article
- [Clinical features of community-acquired bloodstream infection due to Gram-negative bacilli in patients with liver cirrhosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2018Article
- Influence of proton pump inhibitors in the development of spontaneous bacterial peritonitis.World journal of hepatology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsAn increased frequency of infections by multiresistant bacteria has been described in hospitalized patients. The aim of this study was to evaluate the bacterial resistance profile in cirrhotic patients.
methodsThis is a retrospective observational study. We assessed the antimicrobial susceptibility of 5,839 bacterial isolates from patients with and without cirrhosis. Regarding the multidrug resistance, we evaluated 4,505 bacterial isolates from 2,180 patients.
resultsTwo hundred and fifty-one patients had cirrhosis (mean age 57.6 ± 11 years; 61.8% were male, 47.8% of cases associated with hepatitis C virus). Of the isolates of patients with and without cirrhosis, 174/464 (37.5%) and 1,783/4,041 (44.1%) were multiresistant, respectively (p = 0.007). E. coli was the most common multiresistant bacteria in both groups. Approximately 20% of E. coli and Klebsiella sp. isolates were ESBL-producers and 44% of S. aureus isolates were methicillin-resistant in cirrhotic patients. In cirrhotic patients admitted to the emergency department, hospital ward, and intensive care unit, 28.3%, 50% and 40% had multiresistant isolates, respectively. In patients with and without cirrhosis, 36.2% and 33.5% of isolates were resistant to third-generation cephalosporins, respectively.
conclusionsThe empirical treatment of infections in hospitalized patients using broad-spectrum antibiotics should consider the observed pattern of bacterial resistance.
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