Evidence map›Paper›PMID 27253421›Full record

ArticlePloS one2016

ACVR1B rs2854464 Is Associated with Sprint/Power Athletic Status in a Large Cohort of Europeans but Not Brazilians.

Sarah Voisin, João Paulo F L Guilherme, Xu Yan, Vladimir P Pushkarev, Pawel Cieszczyk, Myosotis Massidda, Carla M Calò, Dmitry A Dyatlov, Vitaliy A Kolupaev, Yuliya E Pushkareva and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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  13. The Short Tandem Repeat of theInternational journal of genomics · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 6 countries.

Sarah VoisinINRA, UMR1198 Biologie du Développement et Reproduction, F-78350, Jouy-en-Josas, France.
João Paulo F L GuilhermeSchool of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.
Xu YanInstitute of Sport, Exercise and Active Living (ISEAL), Victoria University, Victoria, Melbourne, Australia.
Vladimir P PushkarevLaboratory of Radiation Genetics, Urals Research Centre for Radiation Medicine of the Federal Medical-Biological Agency of Russia, Chelyabinsk, Russia.
Pawel CieszczykAcademy of Physical Education and Sport, Department of Tourism and Recreation, Gdansk, Poland.
Myosotis MassiddaDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Carla M CalòDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Dmitry A DyatlovUral State University of Physical Culture, Chelyabinsk, Russia.
Vitaliy A KolupaevUral State University of Physical Culture, Chelyabinsk, Russia.
Yuliya E PushkarevaSouth Ural State Medical University, Chelyabinsk, Russia.
Agnieszka MaciejewskaDepartment of Physical Culture and Health Promotion, University of Szczecin, Szczecin Poland.
Marek SawczukDepartment of Physical Culture and Health Promotion, University of Szczecin, Szczecin Poland.
Antonio H LanchaSchool of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.
Guilherme G ArtioliSchool of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.
Nir EynonInstitute of Sport, Exercise and Active Living (ISEAL), Victoria University, Victoria, Melbourne, Australia.ORCID http://orcid.org/0000-0003-4046-8276
Universidade de São Paulo · BRUniversity of Szczecin · PLUniversity of Cagliari · ITUral State University of Physical Culture · RUVictoria University · AUChelyabinsk State Medical Academy · RUChelyabinsk State University · RULaboratoire de Biologie du Développement · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle strength and mass, major contributors to sprint/power athletic performance, are influenced by genetics. However, to date, only a handful of genetic variants have been associated with sprint/power performance. The ACVR1B A allele (rs rs2854464) has previously been associated with increased muscle-strength in non-athletic cohort. However, no follow-up and/or replications studies have since been conducted. Therefore, the aim of the present study was to compare the genotype distribution of ACVR1B rs2854464 between endurance athletes (E), sprint/power (S/P) athletes, mixed athletes (M), and non-athletic control participants in 1672 athletes (endurance athletes, n = 482; sprint/power athletes, n = 578; mixed athletes, n = 498) and 1089 controls (C) of both European Caucasians (Italian, Polish and Russians) and Brazilians. We have also compared the genotype distribution according to the athlete's level of competition (elite vs. sub-elite). DNA extraction and genotyping were performed using various methods. Fisher's exact test (adjusted for multiple comparisons) was used to test whether the genotype distribution of rs2854464 (AA, AG and GG) differs between groups. The A allele was overrepresented in S/P athletes compared with C in the Caucasian sample (adjusted p = 0.048), whereas there were no differences in genotype distribution between E athletes and C, in neither the Brazilian nor the Caucasian samples (adjusted p > 0.05). When comparing all Caucasian athletes regardless of their sporting discipline to C, we found that the A allele was overrepresented in athletes compared to C (adjusted p = 0.024). This association was even more pronounced when only elite-level athletes were considered (adjusted p = 0.00017). In conclusion, in a relatively large cohort of athletes from Europe and South America we have shown that the ACVR1B rs2854464 A allele is associated with sprint/power performance in Caucasians but not in Brazilian athletes. This reinforces the notion that phenotype-genotype associations may be ethnicity-dependent.

Indexed as

Athletic PerformanceGenetic Association StudiesActivin Receptors, Type IAthletesBrazilFemaleGene FrequencyHumansMaleMuscle StrengthPhysical EndurancePolandPolymorphism, Single NucleotideRussiaSouth AmericaWhite PeopleActivin Receptors, Type IACVR1B protein, human

Identifiers

PMID27253421
PMCPMC4890799
OpenAlexW2410487570

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.