ArticlePloS one2016
Longitudinal Changes in White Matter Tract Integrity across the Adult Lifespan and Its Relation to Cortical Thinning.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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Who cites it
45 citing papers in PubMed, 75 citations in OpenAlex.
- Covert Embolic Brain Infarcts, Remote Cortical Thinning, and Cognitive Impairment in Atrial Fibrillation: An Analysis of the Swiss-AF Cohort.Cerebrovascular diseases (Basel, Switzerland) · 2026Article
- Variations in perfusion detectable in advance of microstructure in white matter aging.GeroScience · 2026Article
- Differential tractography suggests a "left-to-whole" white matter degeneration pattern in aging.Brain imaging and behavior · 2026Article
- Biological brain aging, cognitive-motor decline and vascular risk: a multivariate imaging analysis of 40,579 individuals.Frontiers in aging neuroscience · 2026Article
- Variation in brain aging: A review and perspective on the utility of individualized approaches to the study of functional networks in aging.Neurobiology of aging · 2025Review
- BrainAgeNeXt: Advancing brain age modeling for individuals with multiple sclerosis.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Global and tract-specific differences between younger and older adults in DTI measures of white matter integrity.Frontiers in aging neuroscience · 2025Article
- Frontotemporal structure preservation underlies the protective effect of lifetime intellectual cognitive reserve on cognition in the elderly.Alzheimer's research & therapy · 2024Article
- Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure.Annals of clinical and translational neurology · 2024Article
- Tract-based analyses of white matter in schizophrenia, bipolar disorder, aging, and dementia using high spatial and directional resolution diffusion imaging: a pilot study.Frontiers in psychiatry · 2024Article
- White matter tract microstructure, macrostructure, and associated cortical gray matter morphology across the lifespan.bioRxiv : the preprint server for biology · 2023Article
- Automated three-dimensional major white matter bundle segmentation using diffusion magnetic resonance imaging.Anatomical science international · 2023Review
- Brain-wide associations between white matter and age highlight the role of fornix microstructure in brain ageing.Human brain mapping · 2023Article
- Brain imaging and neuropsychological assessment of individuals recovered from a mild to moderate SARS-CoV-2 infection.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Superficial white matter across development, young adulthood, and aging: volume, thickness, and relationship with cortical features.Brain structure & function · 2023Article
- Adult lifespan maturation and degeneration patterns in gray and white matter: A mean apparent propagator (MAP) MRI study.Neurobiology of aging · 2023Article
- Within-person changes in the aging white matter microstructure and their modifiers: A meta-analysis and systematic review of longitudinal diffusion tensor imaging studies.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Neurocognitive considerations in the treatment of meningioma with radiation therapy: applications for quantitative neuroimaging and precision radiation medicine.Journal of neuro-oncology · 2023Review
- White matter tract microstructure, macrostructure, and associated cortical gray matter morphology across the lifespan.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Short superficial white matter and aging: a longitudinal multi-site study of 1293 subjects and 2711 sessions.Aging brain · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
A causal link between decreases in white matter (WM) integrity and cortical degeneration is assumed, but there is scarce knowledge on the relationship between these changes across the adult human lifespan. We investigated changes in thickness throughout the cortical mantle and WM tract integrity derived from T1 and diffusion weighted magnetic resonance imaging (MRI) scans in 201 healthy adults aged 23-87 years over a mean interval of 3.6 years. Fractional anisotropy (FA), mean (MD), radial (RD) and axial (AD) diffusivity changes were calculated for forceps minor and major and eight major white matter tracts in each hemisphere by use of a novel automated longitudinal tractography constrained by underlying anatomy (TRACULA) approach. We hypothesized that increasing MD and decreasing FA across tracts would relate to cortical thinning, with some anatomical specificity. WM integrity decreased across tracts non-uniformly, with mean annual percentage decreases ranging from 0.20 in the Inferior Longitudinal Fasciculus to 0.65 in the Superior Longitudinal Fasciculus. For most tracts, greater MD increases and FA decreases related to more cortical thinning, in areas in part overlapping with but also outside the projected tract endings. The findings indicate a combination of global and tract-specific relationships between WM integrity and cortical thinning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.