Evidence map›Paper›PMID 27253071›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2016

Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore.

Xiao-Dong Zhang, Huasen Wang, Alexander L Antaris, Lulin Li, Shuo Diao, Rui Ma, Andy Nguyen, Guosong Hong, Zhuoran Ma, Joy Wang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Molecular fluorophores for in vivo bioimaging in the second near-infrared window.European journal of nuclear medicine and molecular imaging · 2022
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Atomically Precise Clusterzymes: A Programmable Optoelectronic Platform for Neuroscience.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Article
  7. Ultrabright NIR-II Nanoprobes forACS nanoscience Au · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Multiplexed Shortwave Infrared Imaging Highlights Anatomical Structures in Mice.Angewandte Chemie (International ed. in English) · 2024
    Article
  16. An ultra-small organic dye nanocluster for enhancing NIR-II imaging-guided surgery outcomes.European journal of nuclear medicine and molecular imaging · 2024
    Article
  17. Review
  18. Review
  19. Article
  20. Article

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xiao-Dong ZhangDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Huasen WangDepartment of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen, 518055, P. R. China.
Alexander L AntarisDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Lulin LiPalo Alto Veterans Institute for Research, VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
Shuo DiaoDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Rui MaDepartment of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen, 518055, P. R. China.
Andy NguyenPalo Alto Veterans Institute for Research, VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
Guosong HongDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Zhuoran MaDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Joy WangDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Shoujun ZhuDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Joseph M CastellanoDepartment of Neurology and Neurological Sciences, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Yongye LiangDepartment of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen, 518055, P. R. China.
Jian LuoDepartment of Neurology and Neurological Sciences, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Hongjie DaiDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.

Funding

TGF-β Signaling as a Novel Therapeutic Target for Mild Traumatic Brain InjuryR01NS092868 · NINDS · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI LUO, JIAN · 2016 to 2020
$1.5M
Aging and Inflammation in Mild Traumatic Brain InjuryI01RX001218 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI WYSS-CORAY, TONY · 2014 to 2018
–
NINDS NIH HHS R01 NS092868RRD VA I01 RX001218
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. A bright, renal-excreted, and biocompatible near-infrared II fluorophore for in vivo imaging of TBI is designed. A transient hypoperfusion in the injured cerebral region, followed by fluorophore leakage, is observed. NIR-II fluorophores can provide noninvasive assessment of TBI.

Indexed as

AnimalsBrain Injuries, TraumaticDisease Models, AnimalFluorescent DyesMiceFluorescent Dyesmolecular fluorophoresnear-infrared II fluorescence imagingtraumatic brain injury

Identifiers

PMID27253071
PMCPMC5293734

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.