ArticleArchives of public health = Archives belges de sante publique2016
Acute mountain sickness among tourists visiting the high-altitude city of Lhasa at 3658 m above sea level: a cross-sectional study.
Article in Archives of public health = Archives belges de sante publique, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- A Meta-Analysis of Multidimensional Cognitive Functions Changes in Different Intensities of High-Altitude Hypoxia.Brain and behavior · 2025Pooled it
- Advancing high-altitude medicine: a model for the future.Signal transduction and targeted therapy · 2026Review
- From lactate to lactylation: novel pathological mechanisms and potential therapeutic targets for high-altitude cerebral oedema.Expert reviews in molecular medicine · 2026Review
- Review
- Transcriptomic profiling and targeted validation reveal molecular mechanisms of oxygen therapy in high-altitude cerebral injury.Frontiers in neuroscience · 2026Article
- Susceptibility to mild and severe acute mountain sickness is associated with distinct urine metabolite profiles.Frontiers in physiology · 2026Article
- Integrative Genomic, Transcriptomic and Epigenomic Analysis Reveals cis-regulatory Contributions to High-altitude Adaptation in Tibetan Pigs.Molecular biology and evolution · 2025Article
- Gut microbiota and OMVs: Unveiling novel regulatory mechanisms in high-altitude myocardial injury.iMetaOmics · 2025Article
- Acute high-altitude illness: risk factors, susceptibility prediction, and personalized prevention and treatment.Frontiers in medicine · 2025Review
- Altitude illnesses.Nature reviews. Disease primers · 2024Review
- Short-Term Intermittent Normobaric Hypoxia Combined with Light Exercise Improves Acclimatization of Cardiorespiratory Function in Inactive Adults.Open access journal of sports medicine · 2024Article
- Flying to high-altitude destinations: Is the risk of acute mountain sickness greater?Journal of travel medicine · 2023Review
- AZU1 (HBP/CAP37) and PRKCG (PKC-gamma) may be candidate genes affecting the severity of acute mountain sickness.BMC medical genomics · 2023Article
- Pathophysiology and Therapy of High-Altitude Sickness: Practical Approach in Emergency and Critical Care.Journal of clinical medicine · 2022Review
- Urinary metabolic modulation in human participants residing in Siachen: a 1H NMR metabolomics approach.Scientific reports · 2022Article
- Mitochondrial DNA Variation Correlated With the High Altitude Intolerance in Chinese Young Han Males.Frontiers in cardiovascular medicine · 2022Article
- Physiological responses during ascent to high altitude and the incidence of acute mountain sickness.Physiological reports · 2021Article
- Acute Altitude Acclimatization in Young Healthy Volunteers: Nocturnal Oxygenation Increases Over Time, Whereas Periodic Breathing Persists.High altitude medicine & biology · 2021Article
- Sex-Dependent Association Between Early Morning Ambulatory Blood Pressure Variations and Acute Mountain Sickness.Frontiers in physiology · 2021Article
- Association between physiological responses after exercise at low altitude and acute mountain sickness upon ascent is sex-dependent.Military Medical Research · 2020Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTraveling to Tibet implies a risk for developing acute mountain sickness (AMS), and the size of this problem is likely increasing due to the rising number of tourists. No previous study on AMS has been conducted among the general tourist population in Tibet. Thus, the aim of this study was to estimate the prevalence and determinants of AMS in a large tourist population visiting Lhasa.
methodsA sample of 2385 tourists was recruited from seven randomly selected hotels in Lhasa between June and October 2010. Within three days of their first arrival, the participants filled in a questionnaire based on the Lake Louise Scoring System (LLSS) about AMS-related symptoms and potential contributing factors. AMS was defined as the presence of headache and a cumulative Lake Louise Score ≥4. After estimating the prevalence of AMS, a Log-Binomial Model was applied to analyse the relationship between AMS and selected risk factors.
resultsThe prevalence of AMS was 36.7 % (95 % CI: 34.6-38.7 %) and was not dependent on tourists' country of origin. Among the participants who developed AMS, 47.6 % reported that they experienced symptoms within the first 12 h after arriving in Lhasa, and 79.0 % reported that they had to reduce their activity level. A poor or average health condition (adjusted PR 1.63, 95 % CI 1.38-1.93), an age below 55 years (adjusted PR 1.29, 95 % CI 1.04-1.60), a rapid ascent to Lhasa (adjusted PR 1.17, 95 % CI 1.02-1.34) were independent AMS risk factors, while smoking (adjusted PR 0.75, 95 % CI 0.59-0.96) and pre-exposure to high altitude (adjusted PR 0.71, 95 % CI 0.60-0.84) reduced the risk of AMS.
conclusionsAMS is commonly experienced by tourists visiting Lhasa Tibet, and often affects their activities. The tourists' country of origin did not seem to affect their risk of AMS, and their age was inversely related to AMS. Subjects planning to visit a high-altitude area should be prepared for experiencing AMS-related problems, and consider preventive measures such as pre-exposure or a gradual ascent to high altitudes.
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