ArticleFrontiers in human neuroscience2016
Common Genetic Variant in VIT Is Associated with Human Brain Asymmetry.
Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
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- A missense variant in SHARPIN mediates Alzheimer's disease-specific brain damages.Translational psychiatry · 2021Article
- GWAS-Based Identification of New Loci for Milk Yield, Fat, and Protein in Holstein Cattle.Animals : an open access journal from MDPI · 2020Article
- Genome-Wide Search for SNP Interactions in GWAS Data: Algorithm, Feasibility, Replication Using Schizophrenia Datasets.Frontiers in genetics · 2020Article
- An Exploratory Association Analysis of the Insulin Gene Region With Diabetes Mellitus in Two Dog Breeds.The Journal of heredity · 2019Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Brain asymmetry varies across individuals. However, genetic factors contributing to this normal variation are largely unknown. Here we studied variation of cortical surface area asymmetry in a large sample of subjects. We performed principal component analysis (PCA) to capture correlated asymmetry variation across cortical regions. We found that caudal and rostral anterior cingulate together account for a substantial part of asymmetry variation among individuals. To find SNPs associated with this subset of brain asymmetry variation we performed a genome-wide association study followed by replication in an independent cohort. We identified one SNP (rs11691187) that had genome-wide significant association (P Combined = 2.40e-08). The rs11691187 is in the first intron of VIT. In a follow-up analysis, we found that VIT gene expression is associated with brain asymmetry in six donors of the Allen Human Brain Atlas. Based on these findings we suggest that VIT contributes to normal brain asymmetry variation. Our results can shed light on disorders associated with altered brain asymmetry.
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