ArticleJournal of clinical microbiology2016
Antimicrobial Susceptibility Patterns of Brachyspira Species Isolated from Swine Herds in the United States.
Article in Journal of clinical microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
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- Determination of tylosin concentration in sow's milk after intramuscular administration.Journal of veterinary research · 2025Article
- Genomic insights into the population structure, antimicrobial resistance, and virulence ofMicrobiology spectrum · 2025Article
- Antimicrobial susceptibility of U.S. porcineJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Predictive Power of Long-Read Whole-Genome Sequencing for Rapid Diagnostics of Multidrug-Resistant Brachyspira hyodysenteriae Strains.Microbiology spectrum · 2023Article
- Article
- In vitro evaluation of gentamicin activity against Spanish field isolates of Brachyspira hyodysenteriae.Porcine health management · 2022Article
- In Vitro Screening of Non-Antibiotic Components to Mitigate Intestinal Lesions Caused byAnimals : an open access journal from MDPI · 2022Article
- Whole-Genome Sequencing ofFrontiers in microbiology · 2021Article
- Functional diversity of microbial ecologies estimated from ancient human coprolites and dental calculus.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Evaluation of a zinc chelate on clinical swine dysentery under field conditions.Porcine health management · 2020Article
- Antibacterial activity of Bacillus species-derived surfactin on Brachyspira hyodysenteriae and Clostridium perfringens.AMB Express · 2019Article
- Optimization of Antimicrobial Treatment to Minimize Resistance Selection.Microbiology spectrum · 2018Review
- Identification of a New Antimicrobial Resistance Gene Provides Fresh Insights Into Pleuromutilin Resistance inFrontiers in microbiology · 2018Article
- An avirulent Brachyspira hyodysenteriae strain elicits intestinal IgA and slows down spread of swine dysentery.Veterinary research · 2017Article
- Characterization and Recognition of Brachyspira hampsonii sp. nov., a Novel Intestinal Spirochete That Is Pathogenic to Pigs.Journal of clinical microbiology · 2016Article
- Complete Genome Sequence of Brachyspira hyodysenteriae Type Strain B-78 (ATCC 27164).Genome announcements · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Outbreaks of swine dysentery, caused by Brachyspira hyodysenteriae and the recently discovered "Brachyspira hampsonii," have reoccurred in North American swine herds since the late 2000s. Additionally, multiple Brachyspira species have been increasingly isolated by North American diagnostic laboratories. In Europe, the reliance on antimicrobial therapy for control of swine dysentery has been followed by reports of antimicrobial resistance over time. The objectives of our study were to determine the antimicrobial susceptibility trends of four Brachyspira species originating from U.S. swine herds and to investigate their associations with the bacterial species, genotypes, and epidemiological origins of the isolates. We evaluated the susceptibility of B. hyodysenteriae, B. hampsonii, Brachyspira pilosicoli, and Brachyspira murdochii to tiamulin, valnemulin, doxycycline, lincomycin, and tylosin by broth microdilution and that to carbadox by agar dilution. In general, Brachyspira species showed high susceptibility to tiamulin, valnemulin, and carbadox, heterogeneous susceptibility to doxycycline, and low susceptibility to lincomycin and tylosin. A trend of decreasing antimicrobial susceptibility by species was observed (B. hampsonii > B. hyodysenteriae > B. murdochii > B. pilosicoli). In general, Brachyspira isolates from the United States were more susceptible to these antimicrobials than were isolates from other countries. Decreased antimicrobial susceptibility was associated with the genotype, stage of production, and production system from which the isolate originated, which highlights the roles of biosecurity and husbandry in disease prevention and control. Finally, this study also highlights the urgent need for Clinical and Laboratory Standards Institute-approved clinical breakpoints for Brachyspira species, to facilitate informed therapeutic and control strategies.
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