ArticleScientific reports2016
Tomato 26S Proteasome subunit RPT4a regulates ToLCNDV transcription and activates hypersensitive response in tomato.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Plant responses to geminivirus infection: guardians of the plant immunity.Virology journal · 2021Review
- The Ubiquitin Proteasome System as a Double Agent in Plant-Virus Interactions.Plants (Basel, Switzerland) · 2021Review
- Molecular characterization of SlATG18f in response to Tomato leaf curl New Delhi virus infection in tomato and development of a CAPS marker for leaf curl disease tolerance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Resistant Sources and Genetic Control of Resistance to ToLCNDV in Cucumber.Microorganisms · 2021Article
- Article
- RNA-Seq Transcriptome Analysis Provides Candidate Genes for Resistance toFrontiers in plant science · 2021Article
- Geminivirus Resistance: A Minireview.Frontiers in plant science · 2020Review
- A geminivirus betasatellite encoded βC1 protein interacts with PsbP and subverts PsbP-mediated antiviral defence in plants.Molecular plant pathology · 2019Article
- Plant Antiviral Immunity Against Geminiviruses and Viral Counter-Defense for Survival.Frontiers in microbiology · 2019Review
- The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast.Current genetics · 2018Article
- Gene-targeted Random Mutagenesis to Select Heterochromatin-destabilizing Proteasome Mutants in Fission Yeast.Journal of visualized experiments : JoVE · 2018Article
- Identification, characterization, expression profiling, and virus-induced gene silencing of armadillo repeat-containing proteins in tomato suggest their involvement in tomato leaf curl New Delhi virus resistance.Functional & integrative genomics · 2018Article
- Resistance to tomato leaf curl New Delhi virus in melon is controlled by a major QTL located in chromosome 11.Plant cell reports · 2017Article
- Tomato Leaf Curl New Delhi Virus: An Emerging Virus Complex Threatening Vegetable and Fiber Crops.Viruses · 2017Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Involvement of 26S proteasomal subunits in plant pathogen-interactions, and the roles of each subunit in independently modulating the activity of many intra- and inter-cellular regulators controlling physiological and defense responses of a plant were well reported. In this regard, we aimed to functionally characterize a Solanum lycopersicum 26S proteasomal subunit RPT4a (SlRPT4) gene, which was differentially expressed after Tomato leaf curl New Delhi virus (ToLCNDV) infection in tolerant cultivar H-88-78-1. Molecular analysis revealed that SlRPT4 protein has an active ATPase activity. SlRPT4 could specifically bind to the stem-loop structure of intergenic region (IR), present in both DNA-A and DNA-B molecule of the bipartite viral genome. Lack of secondary structure in replication-associated gene fragment prevented formation of DNA-protein complex suggesting that binding of SlRPT4 with DNA is secondary structure specific. Interestingly, binding of SlRPT4 to IR inhibited the function of RNA Pol-II and subsequently reduced the bi-directional transcription of ToLCNDV genome. Virus-induced gene silencing of SlRPT4 gene incited conversion of tolerant attributes of cultivar H-88-78-1 into susceptibility. Furthermore, transient overexpression of SlRPT4 resulted in activation of programmed cell death and antioxidant enzymes system. Overall, present study highlights non-proteolytic function of SlRPT4 and their participation in defense pathway against virus infection in tomato.
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