Evidence map›Paper›PMID 27252047›Full record

ArticleScientific reports2016

Eyes wide shut: Transcranial alternating current stimulation drives alpha rhythm in a state dependent manner.

Philipp Ruhnau, Toralf Neuling, Marco Fuscá, Christoph S Herrmann, Gianpaolo Demarchi, Nathan Weisz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  13. Bioelectromagnetism in Human Brain Research: New Applications, New Questions.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Philipp RuhnauCenter for Mind/Brain Sciences, University of Trento, via delle Regole 101, 38123 Mattarello, Italy.
Toralf NeulingCenter for Mind/Brain Sciences, University of Trento, via delle Regole 101, 38123 Mattarello, Italy.
Marco FuscáCenter for Mind/Brain Sciences, University of Trento, via delle Regole 101, 38123 Mattarello, Italy.
Christoph S HerrmannExperimental Psychology Lab, Center for Excellence "Hearing4all," European Medical School, University of Oldenburg, 26111 Oldenburg, Germany.
Gianpaolo DemarchiCenter for Mind/Brain Sciences, University of Trento, via delle Regole 101, 38123 Mattarello, Italy.
Nathan WeiszCenter for Mind/Brain Sciences, University of Trento, via delle Regole 101, 38123 Mattarello, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcranial alternating current stimulation (tACS) is used to modulate brain oscillations to measure changes in cognitive function. It is only since recently that brain activity in human subjects during tACS can be investigated. The present study aims to investigate the phase relationship between the external tACS signal and concurrent brain activity. Subjects were stimulated with tACS at individual alpha frequency during eyes open and eyes closed resting states. Electrodes were placed at Cz and Oz, which should affect parieto-occipital areas most strongly. Source space magnetoencephalography (MEG) data were used to estimate phase coherence between tACS and brain activity. Phase coherence was significantly increased in areas in the occipital pole in eyes open resting state only. The lag between tACS and brain responses showed considerable inter-individual variability. In conclusion, tACS at individual alpha frequency entrains brain activity in visual cortices. Interestingly, this effect is state dependent and is clearly observed with eyes open but only to a lesser extent with eyes closed.

Indexed as

Ocular Physiological PhenomenaAdultAlpha RhythmBrain MappingCognitionFemaleHumansMagnetoencephalographyMaleTranscranial Direct Current StimulationVisual Cortex

Identifiers

PMID27252047
PMCPMC4890046

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.