Evidence map›Paper›PMID 27251790›Full record

ArticleThe Journal of investigative dermatology2016

Association of Melanocortin-1 Receptor Variants with Pigmentary Traits in Humans: A Pooled Analysis from the M-Skip Project.

Elena Tagliabue, Sara Gandini, José C García-Borrón, Patrick Maisonneuve, Julia Newton-Bishop, David Polsky, DeAnn Lazovich, Rajiv Kumar, Paola Ghiorzo, Leah Ferrucci and 17 more

Open access · bronzeAbstract readComparative StudyLetter
In one paragraph

Article in The Journal of investigative dermatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Unique Features of Melanoma Risk and Diagnosis in Red-Haired Populations.International journal of molecular sciences · 2026
    Review
  2. Article
  3. An overview of benefits and risks of chronic melanocortin-1 receptor activation.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
    Review
  4. Article
  5. Reflectance Confocal Microscopy of Aging Skin and Skin Cancer.Dermatology practical & conceptual · 2021
    Review
  6. Article
  7. Article
  8. Article
  9. Mechanisms and prevention of UV-induced melanoma.Photodermatology, photoimmunology & photomedicine · 2018
    Review
  10. Cancer management and research · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 20 institutions in 12 countries.

Elena TagliabueDivision of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy.
Sara GandiniDivision of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy.
José C García-BorrónDepartment of Biochemistry, Molecular Biology and Immunology, University of Murcia and IMIB-Arrixaca, Murcia, Spain.
Patrick MaisonneuveDivision of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy.
Julia Newton-BishopSection of Epidemiology and Biostatistics, Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
David PolskyThe Ronald O. Perelman Department of Dermatology, New York University School of Medicine, NYU Langone Medical Center, New York, New York, USA.
DeAnn LazovichDivision of Epidemiology and Community Health, University of Minnesota, Minnesota, USA.
Rajiv KumarDivision of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Paola GhiorzoDepartment of Internal Medicine and Medical Specialties, University of Genoa, Italy; IRCCS AOU San Martino-IST, Genoa, Italy.
Leah FerrucciDepartment of Chronic Disease Epidemiology, Yale School of Public Health, Yale Cancer Center, New Haven, Connecticut, USA.
Nelleke A GruisDepartment of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
Susana PuigMelanoma Unit, Dermatology Department, Hospital Clinic Barcelona, University of Barcelona, CIBER de Enfermedades Raras, Spain.
Peter A KanetskyDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute2, Tampa, Florida, USA.
Tomonori MotokawaSkin Research Department, POLA Chemical Industries, Yokohama, Japan.
Gloria RibasDepartment of medical oncology and hematology, Fundación Investigación Clínico de Valencia Instituto de Investigación Sanitaria- INCLIVA, Valencia, Spain.
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Maria Concetta FargnoliDepartment of Dermatology, University of L'Aquila, L'Aquila, Italy.
Terence H WongNHS Forth Valley, UK.
Alexander StratigosFirst Department of Dermatology, Andreas Sygros Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Per HelsingDepartment of Pathology, Oslo University Hospital, Oslo, Norway.
Gabriella GuidaDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Bari, Italy.
Philippe AutierInternational Prevention Research Institute, Lyon, France.
Jiali HanDepartment of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana, USA.
Julian LittleSchool of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Canada.
Francesco SeraDepartment of Social and Environmental Health Research, London School of Hygiene & Tropical Medicine, London, UK.
Sara RaimondiDivision of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy. Electronic address: sara.raimondi@ieo.it.
M-SKIP Study group
European Institute of Oncology · ITUniversity of Leeds · GBCentro de Investigación Biomédica en Red · ESMoffitt Cancer Center · USNHS Forth Valley · GBNYU Langone Health · USOslo University Hospital · NOPola Chemical Industries (Japan) · JPUniversity of Bari Aldo Moro · ITGerman Cancer Research Center · DEINCLIVA Health Research Institute · ESIndiana University Health · USInternational Prevention Research Institute · FRLeiden University Medical Center · NLLondon School of Hygiene & Tropical Medicine · GBNational and Kapodistrian University of Athens · GRNational Cancer Institute · USOspedale Policlinico San Martino · ITUniversidad de Murcia · ESUniversity of L'Aquila · IT

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
Molecular Epidemiology of MelanomaR01CA092428 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KANETSKY, PETER A · 2002 to 2006
$2.3M
MELANOMA AND ALLELIC VARIATION IN THE MCIR GENEK07CA080700 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KANETSKY, PETER A · 2000 to 2005
$634k
Cancer Research UK 10589Cancer Research UK 19167NCATS NIH HHS UL1 TR001863NCI NIH HHS K07 CA080700NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA092428NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AllelesCyclic AMPEye ColorGenetic HeterogeneityHair ColorHumansMelanocytesMelanosisPhenotypePolymorphism, Single NucleotideReceptor, Melanocortin, Type 1Skin PigmentationCyclic AMPReceptor, Melanocortin, Type 1

Identifiers

PMID27251790
PMCPMC5317175
OpenAlexW2395771477

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.