ArticleOpen biology2016
Identification of zinc finger protein Bcl6 as a novel regulator of early adipose commitment.
Article in Open biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Transcription factor PATZ1 promotes adipogenesis by controlling promoter regulatory loci of adipogenic factors.Nature communications · 2024Article
- Review
- Blautia Coccoides is a Newly Identified Bacterium Increased by Leucine Deprivation and has a Novel Function in Improving Metabolic Disorders.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- MORA and EnsembleTFpredictor: An ensemble approach to reveal functional transcription factor regulatory networks.PloS one · 2023Article
- Assessing Population Structure and Signatures of Selection in Wanbei Pigs Using Whole Genome Resequencing Data.Animals : an open access journal from MDPI · 2022Article
- Comprehensive analysis of epigenomics and transcriptome data to identify potential target genes associated with obesity.Frontiers in genetics · 2022Article
- Epigenetic Regulators of White Adipocyte Browning.Epigenomes · 2021Review
- Novel Insights into Adipogenesis from the Perspective of Transcriptional and RNA N6-Methyladenosine-Mediated Post-Transcriptional Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways.International journal of molecular sciences · 2020Review
- Molecular Mechanism of Stem Cell Differentiation into Adipocytes and Adipocyte Differentiation of Malignant Tumor.Stem cells international · 2020Review
- BCL6 regulates brown adipocyte dormancy to maintain thermogenic reserve and fitness.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Bcl6 knockdown aggravates hypoxia injury in cardiomyocytes via the P38 pathway.Cell biology international · 2019Article
- Loss of Transcriptional Repression by BCL6 Confers Insulin Sensitivity in the Setting of Obesity.Cell reports · 2018Article
- The Emerging Role of Zfp217 in Adipogenesis.International journal of molecular sciences · 2017Article
- Transcriptional Dynamics During Human Adipogenesis and Its Link to Adipose Morphology and Distribution.Diabetes · 2017Article
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Authors and funding
9 authors.
Funding
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Abstract
Adipose tissue is a key determinant of whole-body metabolism and energy homeostasis. Unravelling the transcriptional regulatory process during adipogenesis is therefore highly relevant from a biomedical perspective. In these studies, zinc finger protein B-cell lymphoma 6 (Bcl6) was demonstrated to have a role in early adipogenesis of mesenchymal stem cells. Bcl6 is enriched in preadipose versus non-preadipose fibroblasts and shows upregulated expression in the early stage of adipogenesis. Gain- and loss-of-function studies revealed that Bcl6 acts as a key regulator of adipose commitment and differentiation both in vitro and ex vivo RNAi-mediated knockdown of Bcl6 in C3H10T1/2 cells greatly inhibited adipogenic potential, whereas Bcl6 overexpression enhanced adipogenic differentiation. This transcription factor also directly or indirectly targets and controls the expression of some early and late adipogenic regulators (i.e. Zfp423, Zfp467, KLF15, C/EBPδ, C/EBPα and PPARγ). We further identified that Bcl6 transactivated the signal transducers and activators of transcription 1 (STAT1), which was determined as a required factor for adipogenesis. Moreover, overexpression of STAT1 rescued the impairment of adipogenic commitment and differentiation induced by Bcl6 knockdown in C3H10T1/2 cells, thereby confirming that STAT1 is a downstream direct target of Bcl6. This study identifies Bcl6 as a positive transcriptional regulator of early adipose commitment.
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