ArticleBMJ open2016
Association between white blood cell count and non-alcoholic fatty liver disease in urban Han Chinese: a prospective cohort study.
Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Immune-inflammatory biomarkers and immune features in metabolic dysfunction-associated steatotic liver disease: a bibliometric study.Frontiers in immunology · 2026Pooled it
- Leukocyte glucose index discriminates metabolic dysfunction-associated steatotic liver disease from type 2 diabetes: a finding independent of oral antidiabetic therapy.Gastroenterology and hepatology from bed to bench · 2026Article
- Development and progression of hepatic steatosis during long-term glucocorticoid therapy in autoimmune hepatitis: multimodal evidence from biopsy, CAP, and ultrasound.Frontiers in medicine · 2026Article
- Screening for metabolic-associated fatty liver disease in type 2 diabetes patients using non-invasive scores and ultrasound: a cross-sectional study in Egypt.BMC gastroenterology · 2025Article
- Therapeutic Potential ofFood science & nutrition · 2025Article
- Establishing of a risk prediction model for metabolic dysfunction-associated steatotic liver disease: a retrospective cohort study.BMC gastroenterology · 2025Article
- The association between sedentary behavior and MASLD in overweight and obese adults: investigating the role of inflammatory markers using NHANES data (2017-March 2020).Frontiers in nutrition · 2025Article
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- A new perspective on non-invasive diagnosis of non- alcoholic fatty liver disease: evidence integration of inflammatory and metabolic biomarkers based on a scoping review.Frontiers in endocrinology · 2025Article
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- Nonalcoholic Fatty Liver Disease: Changes in Gut Microbiota and Blood Lipids.Journal of clinical and translational hepatology · 2024Article
- Serum Metrnl is Decreased in Metabolic Dysfunction-Associated Fatty Liver Disease: A Case-Control Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Synergistic Effect of Diet and Physical Activity on a NAFLD Cohort: Metabolomics Profile and Clinical Variable Evaluation.Nutrients · 2023Article
- Neutrophils: tissue and circulating signatures of pediatric non-alcoholic fatty liver disease.Frontiers in cell and developmental biology · 2023Review
- Sex-specific metabolic risk factors and their trajectories towards the non-alcoholic fatty liver disease incidence.Journal of endocrinological investigation · 2022Article
- Inflammatory potential of diet and risk of nonalcoholic fatty liver disease: a prospective cohort study.European journal of clinical nutrition · 2022Article
- Chronic Inflammation-A Link between Nonalcoholic Fatty Liver Disease (NAFLD) and Dysfunctional Adipose Tissue.Medicina (Kaunas, Lithuania) · 2022Review
- Article
- Improving the accuracy of fatty liver index to reflect liver fat content with predictive regression modelling.PloS one · 2022Article
- A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe white blood cell (WBC) count is a simple and convenient marker of inflammation for use in medical practice; however, its association with non-alcoholic fatty liver disease (NAFLD) has not been determined. We examined the relationship between WBC and NAFLD to provide a convenient and useful marker for the prediction of NAFLD.
settingA longitudinal cohort participating in a large health check-up programme for the Chinese population was selected and followed up from 2005 to 2011.
participantsA total of 21 307 male and female participants without NAFLD who underwent health check-ups at least twice between 2005 and 2011 were included in this study. 15 201 participants (7286 men and 7915 women) were eligible for inclusion.
resultsThe baseline distribution of age, WBC, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), serum total protein (TP), albumin (ALB) and globin (GLO) and the prevalence of males, hypertension, hyperglycaemia, smoking and regular exercise were significantly different between the incident NAFLD and non-NAFLD groups (p<0.05). Cox proportional hazards regression analysis was performed to estimate the HRs and 95% CIs of WBC, which predicted the occurrence of NAFLD. Compared with the lowest WBC quartile (Q1), the HRs and 95% CIs of the other WBC quartiles (Q2, Q3 and Q4) for incident NAFLD were 1.090 (0.978 to 1.215), 1.174 (1.055 to 1.305) and 1.152 (1.035 to 1.281), respectively, after adjusting for age, gender, smoking, regular exercise, BMI, hypertension, hyperglycaemia, TC, TG, HDL-C, LDL-C, ALB and GLO.
conclusionsOur study clearly showed that WBC count was a significant factor associated with incident NAFLD in Han Chinese.
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