ArticleBMC cancer2016
Ultrasound screening for cholangiocarcinoma could detect premalignant lesions and early-stage diseases with survival benefits: a population-based prospective study of 4,225 subjects in an endemic area.
Article in BMC cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Ontology development and use for cholangiocarcinoma risk factors and predictions: a term enrichment data analysis and machine learning classification.Journal of biomedical semantics · 2026Article
- A Medical Anthropology Assessment of Community Liver Cancer Risks: Qualitative Comparisons of Communities with Different Risk Profiles in Thailand.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Advanced ultrasound diagnosis of extrahepatic bile duct lesions.Journal of medical ultrasonics (2001) · 2025Review
- Sonographic Predictors for Developing Cholangiocarcinoma: A Cohort Study from an Endemic Area.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Enhanced detection ofParasite epidemiology and control · 2024Article
- Improvement of survival outcomes of cholangiocarcinoma by ultrasonography surveillance: Multicenter retrospective cohorts.Heliyon · 2024Article
- Primary Sclerosing Cholangitis Associated With Ulcerative Colitis Coexisting With Cholangiocarcinoma: A Case Report.Cureus · 2024Article
- Current State of Knowledge on Blood and Tissue-Based Biomarkers for Opisthorchis viverrini-induced Cholangiocarcinoma: A Review of Prognostic, Predictive, and Diagnostic Markers.Asian Pacific journal of cancer prevention : APJCP · 2024Review
- High-grade dysplasia of the cystic duct margin: how should this be managed?BMJ case reports · 2023Article
- Cost-Effectiveness Analysis of Ultrasound Surveillance for Cholangiocarcinoma in an Endemic Area of Thailand.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Exhaled volatile organic compounds for cholangiocarcinoma diagnosis.Liver research (Beijing, China) · 2022Article
- Associations between ultrasound screening findings and cholangiocarcinoma diagnosis in an at-risk population.Scientific reports · 2022Article
- Modification of the eighth AJCC/UICC staging system for perihilar cholangiocarcinoma: An alternative pathological staging system from cholangiocarcinoma-prevalent Northeast Thailand.Frontiers in medicine · 2022Article
- Plasma checkpoint protein 1 (Chk1) as a potential diagnostic biomarker for opisthorchiasis and cholangiocarcinoma.Cancer biomarkers : section A of Disease markers · 2022Article
- Survival after surgery among patients with cholangiocarcinoma in Northeast Thailand according to anatomical and morphological classification.BMC cancer · 2021Article
- Stool Examination for Liver Fluke Detection and Ultrasonography for Detection of Abnormal Biliary Tract in Cholangiocarcinoma Control Program: A Reappraisal from Endemic Area in Indochina.International journal of preventive medicine · 2021Article
- Article
- Infection withPathogens (Basel, Switzerland) · 2020Article
- Adenosine Suppresses Cholangiocarcinoma Cell Growth and Invasion in Equilibrative Nucleoside Transporters-Dependent PathwayInternational journal of molecular sciences · 2020Article
- Subsets of Inflammatory Cytokine Gene Polymorphisms are Associated with Risk of Carcinogenic Liver FlukeThe Korean journal of parasitology · 2017Article
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Authors and funding
17 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThailand has a high incidence of cholangiocarcinoma (CCA), particularly in the north and northeastern regions. Most CCA patients come at a late, unresectable stage and presently no optimal screening test for CCA has been established. We determined the prevalence of CCA in a remote northern village and explored if screening could lead to early detection and survival benefits.
methodsA 5-year population-based study was started in October, 2011 for consented Thai individuals, aged 30-60 years. The screening program comprised blood testing, stool examination and serial ultrasonography every 6 months.
resultsDuring the first 3 years, 4,225 eligible individuals were enrolled. CCA was detected in 32 patients, with a mean age of 51.9 years (41-62 years), and 21/32 cases were at a curative resectable stage. The prevalence rate of CCA was 165.7 per 100,000 and one- and two-year incidence rate was 236.7/100,000 and 520.7/100,000, respectively. One- and 2-year overall survival rates of CCA patients were 90.9 and 61.5 %, respectively. Prognosis was better in resectable cases with 100 % 1-year and 77.8 % 2-year survival rates. Interestingly, premalignant pathological lesions (stage 0) were identified in 11 cases with 100 % 3-year survival rate. Serum biomarkers and alkaline phosphatase were not sufficient to detect early-stage disease. In 22 patients, stool samples were positive for Opistorchis viverrini, based on polymerase chain reaction.
conclusionDetection of premalignant lesions and early-stage resectable CCA by ultrasonography resulted in improved clinical outcome. Ultrasonography should be offered as a first screening tool for CCA in an endemic area until other useful biological markers become available.
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