ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
Dopamine Release in the Nonhuman Primate Caudate and Putamen Depends upon Site of Stimulation in the Subthalamic Nucleus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Cellular, molecular, and clinical mechanisms of action of deep brain stimulation-a systematic review on established indications and outlook on future developments.EMBO molecular medicine · 2019Pooled it
- Measurement of electrochemical brain activity with fast-scan cyclic voltammetry during functional magnetic resonance imaging.Nature protocols · 2026Review
- In vivo multimodal neurochemical interfaces for real-time decoding of brain circuit.Nature reviews. Neuroscience · 2026Review
- What can neuroimaging of neuromodulation reveal about the basis of circuit therapies for psychiatry?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- The Subcortical Atlas of the Marmoset ("SAM") monkey based on high-resolution MRI and histology.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The Subcortical Atlas of the Marmoset ("SAM") monkey based on high-resolution MRI and histology.bioRxiv : the preprint server for biology · 2024Article
- Subthalamic nucleus exclusively evokes dopamine release in the tail of the striatum.Journal of neurochemistry · 2022Article
- The role of neurotransmitter systems in mediating deep brain stimulation effects in Parkinson's disease.Frontiers in neuroscience · 2022Review
- High-resolution mapping and digital atlas of subcortical regions in the macaque monkey based on matched MAP-MRI and histology.NeuroImage · 2021Article
- Subthalamic stimulation breaks the balance between distal and axial signs in Parkinson's disease.Scientific reports · 2021Article
- The rostro-caudal gradient in the prefrontal cortex and its modulation by subthalamic deep brain stimulation in Parkinson's disease.Scientific reports · 2021Article
- Defining a Path Toward the Use of Fast-Scan Cyclic Voltammetry in Human Studies.Frontiers in neuroscience · 2021Review
- Animal Models of Tinnitus Treatment: Cochlear and Brain Stimulation.Current topics in behavioral neurosciences · 2021Article
- Whole-Brain Afferent Inputs to the Caudate Nucleus, Putamen, and Accumbens Nucleus in the Tree Shrew Striatum.Frontiers in neuroanatomy · 2021Article
- Longitudinal Changes in Functional Connectivity of the Caudate Is Associated With Recovery From Bell's Palsy.Frontiers in aging neuroscience · 2019Article
- Reward and value coding by dopamine neurons in non-human primates.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Fast-Scan Cyclic Voltammetry: Chemical Sensing in the Brain and Beyond.Analytical chemistry · 2018Review
- The Relationship Between Dopamine Neurotransmitter Dynamics and the Blood-Oxygen-Level-Dependent (BOLD) Signal: A Review of Pharmacological Functional Magnetic Resonance Imaging.Frontiers in neuroscience · 2018Review
- Long-term dopamine neurochemical monitoring in primates.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Subthalamic nucleus and globus pallidus interna influence firing of tonically active neurons in the primate striatum through different mechanisms.The European journal of neuroscience · 2017Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
unlabelledDeep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for medically refractory Parkinson's disease. Although DBS has recognized clinical utility, its biologic mechanisms are not fully understood, and whether dopamine release is a potential factor in those mechanisms is in dispute. We tested the hypothesis that STN DBS-evoked dopamine release depends on the precise location of the stimulation site in the STN and the site of recording in the caudate and putamen. We conducted DBS with miniature, scaled-to-animal size, multicontact electrodes and used functional magnetic resonance imaging to identify the best dopamine recording site in the brains of nonhuman primates (rhesus macaques), which are highly representative of human brain anatomy and circuitry. Real-time stimulation-evoked dopamine release was monitored using in vivo fast-scan cyclic voltammetry. This study demonstrates that STN DBS-evoked dopamine release can be reduced or increased by redirecting STN stimulation to a slightly different site. SIGNIFICANCE STATEMENT: Electrical stimulation of deep structures of the brain, or deep brain stimulation (DBS), is used to modulate pathological brain activity. However, technological limitations and incomplete understanding of the therapeutic mechanisms of DBS prevent personalization of this therapy and may contribute to less-than-optimal outcomes. We have demonstrated that DBS coincides with changes in dopamine neurotransmitter release in the basal ganglia. Here we mapped relationships between DBS and changes in neurochemical activity. Importantly, this study shows that DBS-evoked dopamine release can be reduced or increased by refocusing the DBS on a slightly different stimulation site.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.