Observational studyHeart and vessels2017
Transcatheter aortic valve replacement in nonagenarians: early and intermediate outcome from the OBSERVANT study and meta-analysis of the literature.
Observational study in Heart and vessels, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Clinical Outcomes of Transcatheter Aortic Valve Replacement in Nonagenarians: A Systematic Review and Meta-Analysis.Journal of interventional cardiology · 2019Pooled it
- Ankle-brachial pressure index as a predictor of the 2-year outcome after transcatheter aortic valve replacement: data from the Japanese OCEAN-TAVI Registry.Heart and vessels · 2018Trial
- Health and Social Care Interventions in the 80 years Old and Over Population: An Evidence and Gap Map.Campbell systematic reviews · 2026Review
- Simultaneous transcatheter aortic valve replacement and thoracic endovascular aortic repair by the transcarotid approach for aortic stenosis with chronic type-A aortic dissection.Journal of cardiology cases · 2025Article
- Concomitant Valve Replacement and Coronary Artery Bypass Grafting Surgery: Lessons from the Past, Guidance for the Future? A Mortality Analysis in 294 Patients.Journal of clinical medicine · 2023Article
- Clinical outcomes following transapical TAVR with ACURATEInternational journal of cardiology. Heart & vasculature · 2021Article
- Aortic valve replacement with or without concomitant coronary artery bypass grafting in very elderly patients aged 85 years and older.Heart and vessels · 2020Article
- Does additional coronary artery bypass grafting to aortic valve replacement in elderly patients affect the early and long-term outcome?Heart and vessels · 2020Article
- Transcatheter aortic valve replacement over age 90: Risks vs benefits.Clinical cardiology · 2020Review
- Impact of N-terminal pro-B-type natriuretic peptide response on long-term prognosis after transcatheter aortic valve implantation for severe aortic stenosis and heart failure.Heart and vessels · 2019Article
- Predictors of permanent pacemaker implantation after transcatheter aortic valve implantation for aortic stenosis using Medtronic new generation self-expanding CoreValve Evolut R.Heart and vessels · 2019Article
- Alternate Access for TAVI: Stay Clear of the Chest.Interventional cardiology (London, England) · 2018Review
- A proctoring system to manage the learning curve associated with the introduction of transcatheter aortic valve implantation in Japan.Heart and vessels · 2018Article
- Comparison of in-hospital outcomes between octogenarians and nonagenarians undergoing transcatheter aortic valve replacement: a propensity matched analysis.Journal of geriatric cardiology : JGC · 2018Article
- Transcatheter aortic valve implantation in nonagenarians: selectively feasible or extravagantly futile?Annals of cardiothoracic surgery · 2017Article
- Transcatheter tricuspid valve-in-valve replacement: one-year results : Alternative to surgery in high-risk patients.Heart and vessels · 2017Article
- Do all Critical Aortic Stenosis with Chest Pain Need Aortic Valve Replacement? A Case Report.Clinics and practice · 2016Article
- Role of Imaging in Transcatheter Aortic Valve Replacement.Current treatment options in cardiovascular medicine · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to evaluate the outcome of nonagenarians after transcatheter aortic valve replacement (TAVR) from the OBSERVANT study and to pool the results of the literature on this topic. Aortic stenosis is the most common acquired valvular heart disease in the Western countries, and its prevalence is linked to the phenomenon of population aging. TAVR can be considered as a wise approach to treat nonagenarians, but data on its safety and effectiveness are scarce. Data on 80 patients aged >90 years who underwent TAVR from OBSERVANT study were analyzed. A systematic review and meta-analysis of published data were performed. Thirty-day mortality in the OBSERVANT series was 6.3 %. None of these patients experienced stroke. Permanent pacemaker implantation was necessary in 20 % of patients. Paravalvular regurgitation was observed in 57.5 %. Survival at 1, 2, and 3 years was 79.6, 71.9, and 61.5 %. Ten series provided data on 1227 nonagenarians who underwent TAVR. Pooled 30-day mortality rate was 7.1 %, stroke 2.8 %, vascular access complication 8.8 %, and permanent pacemaker implantation 10.6 %. Paravalvular regurgitation was observed in 60.1 % of patients. Pooled 1-, 2-, and 3-year survival rates were 79.2, 68.2, and 55.6 %. Transapical TAVR was associated with a significantly higher risk of early mortality compared with transfemoral TAVR. The results of OBSERVANT study and aggregate data meta-analysis suggest that in nonagenarians, TAVR is associated with low postoperative morbidity and excellent intermediate survival. Transapical TAVR in these very elderly is associated with high postoperative mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.