Evidence map›Paper›PMID 27251471›Full record

ReviewReviews of physiology, biochemistry and pharmacology

Functional Impact of Ryanodine Receptor Oxidation on Intracellular Calcium Regulation in the Heart.

Aleksey V Zima, Stefan R Mazurek

Open access · greenAbstract readReview
In one paragraph

Review in Reviews of physiology, biochemistry and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 44 citations in OpenAlex.

  1. Sex determines cardiac and renal Vulnerability to chronic hemoglobin toxicity.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
    Article
  2. Article
  3. Acellular Hemoglobin Impairs Cardiomyocyte Excitation-Contraction Coupling.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026
    Article
  4. Oxidative Modifications in Cardiac Mitochondrial and CaHandbook of experimental pharmacology · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. RyR2 and Calcium Release in Heart Failure.Frontiers in physiology · 2021
    Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aleksey V ZimaDepartment of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, 2160 South First Avenue, Maywood, IL, 60153, USA. azima@luc.edu.
Stefan R MazurekDepartment of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, 2160 South First Avenue, Maywood, IL, 60153, USA.
Loyola University Chicago · US

Funding

MULTIDISCIPLINARY CARDIAC SCIENCEST32HL007381 · NHLBI · UNIVERSITY OF CHICAGO · PI JEANNE M DECARA, Yoav Gilad · 1985 to 2026
$12.5M
Calcium release channel dysfunction: molecular mechanismsR01HL130231 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI ZIMA, ALEKSEY V · 2016 to 2019
$1.5M
NHLBI NIH HHS R01 HL130231NHLBI NIH HHS T32 HL007381
6 · The paper itself

Abstract

Type 2 ryanodine receptor (RyR2) serves as the major intracellular Ca

Indexed as

Oxidative StressAnimalsCalciumHeart FailureHumansMyocardial ContractionMyocardial Reperfusion InjuryMyocardiumRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumCalciumRyanodine Receptor Calcium Release ChannelCa releaseGlutathioneHeartReactive oxygen speciesRyanodine receptorSarcoplasmic reticulum

Identifiers

PMID27251471
PMCPMC5033687
OpenAlexW2463184389

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.