Evidence map›Paper›PMID 27251436›Full record

ArticleAIDS and behavior2017

Depression and Engagement in Care Among Newly Diagnosed HIV-Infected Adults in Johannesburg, South Africa.

R Cholera, B W Pence, B N Gaynes, J Bassett, N Qangule, A Pettifor, C Macphail, W C Miller

Open access · greenAbstract read
In one paragraph

Article in AIDS and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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  17. Perceptions and attitudes of black men in a rural district of South Africa towards depression and its treatment.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2022
    Article
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  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

R CholeraUNC School of Medicine, Pediatric Education Office, 230 MacNider Hall, Campus Box 7593, Chapel Hill, NC, 27599, USA. rushina.cholera@unchealth.unc.edu.
B W PenceDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
B N GaynesDepartment of Psychiatry, UNC School of Medicine, Chapel Hill, NC, USA.
J BassettWitkoppen Health and Welfare Center, Johannesburg, South Africa.
N QanguleWitkoppen Health and Welfare Center, Johannesburg, South Africa.
A PettiforDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
C MacphailCollaborative Research Network for Mental Health and Well-being in Rural Communities, University of New England, Armidale, Australia.
W C MillerDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · USUniversity of North Carolina Health Care · USUniversity of New England · AU

Funding

UNC CLINICAL AND TRANSLATIONAL SCIENCE AWARD: BPCAUL1RR025747 · NCRR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUNGE, MARSCHALL S. · 2008 to 2011
$44.6M
Fogarty Global Health Fellows Coordinating CenterR25TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHI, BENJAMIN H. · 2012 to 2016
$6.9M
Acute HIV infection - A key link for transmission preventionR01AI083059 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MILLER, WILLIAM C, PETTIFOR, AUDREY · 2009 to 2012
$3.7M
Psychosocial Barriers to Engagement in Care in Young South African Women with HIVF30MH096664 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHOLERA, RUSHINA · 2011 to 2015
$143k
FIC NIH HHS R25 TW009340NCRR NIH HHS UL1 RR025747NIAID NIH HHS R01 AI083059NIMH NIH HHS F30 MH096664
6 · The paper itself

Abstract

Delayed engagement in HIV care threatens the success of HIV treatment programs in sub-Saharan Africa and may be influenced by depression. We examined the relationship between depression prior to HIV diagnosis and engagement in HIV care at a primary care clinic in Johannesburg, South Africa. We screened 1683 patients for depression prior to HIV testing using the Patient Health Questionnaire-9. Among patients who tested positive for HIV we assessed linkage to HIV care, defined as obtaining a CD4 count within 3 months. Among those who linked to care and were eligible for ART, we assessed ART initiation within 3 months. Multivariable Poisson regression with a robust variance estimator was used to assess the association between depression and linkage to care or ART initiation. The prevalence of HIV was 26 % (n = 340). Among HIV-infected participants, the prevalence of depression was 30 %. The proportion of linkage to care was 80 % among depressed patients and 73 % among patients who were not depressed (risk ratio 1.08; 95 % confidence interval 0.96, 1.23). Of the participants who linked to care, 81 % initiated ART within 3 months in both depressed and not depressed groups (risk ratio 0.99; 95 % confidence interval 0.86, 1.15). Depression was not associated with engagement in HIV care in this South African primary care setting. Our unexpected findings suggest that some depressed HIV-infected patients might be more likely to engage in care than their counterparts without depression, and highlight the complex relationship between depression and HIV infection. These findings have led us to propose a new framework relating HIV infection, depression, and the population under study.

Indexed as

Patient Acceptance of Health CareAdolescentAdultAIDS SerodiagnosisAnti-HIV AgentsCD4 Lymphocyte CountDepressionDepressive DisorderFemaleHIV InfectionsHumansMaleMass ScreeningMiddle AgedPrevalencePrimary Health CareAnti-HIV AgentsAfricaDepressionEngagement in careHIV

Identifiers

PMID27251436
PMCPMC8741408
OpenAlexW2467072970

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.