ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life2017
Dissolved Divalent Metal and pH Effects on Amino Acid Polymerization: A Thermodynamic Evaluation.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- From Catalysis of Evolution to Evolution of Catalysis.Accounts of chemical research · 2024Article
- Adsorbents for the Uranium Capture from Seawater for a Clean Energy Source and Environmental Safety: A Review.ACS omega · 2024Review
- Spark of Life: Role of Electrotrophy in the Emergence of Life.Life (Basel, Switzerland) · 2023Review
- Copper acetate aerosols: A possible tool complementary to vaccination in fight against SARS-CoV-2 and variants replication.Medical hypotheses · 2022Article
- Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine.RSC advances · 2021Article
- Article
- Environmental control programs the emergence of distinct functional ensembles from unconstrained chemical reactions.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Amorphous Silica-Promoted Lysine Dimerization: a Thermodynamic Prediction.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2018Article
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Authors and funding
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Abstract
Polymerization of amino acids is a fundamentally important step for the chemical evolution of life. Nevertheless, its response to changing environmental conditions has not yet been well understood because of the lack of reliable quantitative information. For thermodynamics, detailed prediction over diverse combinations of temperature and pH has been made only for a few amino acid-peptide systems. This study used recently reported thermodynamic dataset for the polymerization of the simplest amino acid "glycine (Gly)" to its short peptides (di-glycine and tri-glycine) to examine chemical and structural characteristics of amino acids and peptides that control the temperature and pH dependence of polymerization. Results showed that the dependency is strongly controlled by the intramolecular distance between the amino and carboxyl groups in an amino acid structure, although the side-chain group role is minor. The polymerization behavior of Gly reported earlier in the literature is therefore expected to be a typical feature for those of α-amino acids. Equilibrium calculations were conducted to examine effects of dissolved metals as a function of pH on the monomer-polymer equilibria of Gly. Results showed that metals shift the equilibria toward the monomer side, particularly at neutral and alkaline pH. Metals that form weak interaction with Gly (e.g., Mg
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Registered trials
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