ArticleClinical oral investigations2017
A novel blue light laser system for surgical applications in dentistry: evaluation of specific laser-tissue interactions in monolayer cultures.
Article in Clinical oral investigations, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- "Laser assisted gingival melanin depigmentation using diode 450 nm; ablative vs. non-ablative techniques: randomized clinical trial".Lasers in medical science · 2025Trial
- Maxillary labial frenectomy: a randomized, controlled comparative study of two blue (445 nm) and infrared (980 nm) diode lasers versus surgical scalpel.BMC oral health · 2024Trial
- Wound healing after therapy of oral potentially malignant disorders with a 445-nm semiconductor laser: a randomized clinical trial.Clinical oral investigations · 2023Trial
- Precise ablation of cholesteatoma using a 445-nm diode laser.Scientific reports · 2026Article
- Evaluation of the Inactivation of Microorganisms by a Blue Laser (445 nm)-An In Vitro Study.Antibiotics (Basel, Switzerland) · 2026Article
- Bacterial reduction and temperature increase of titanium dental implant models treated with a 445 nm diode laser: an in vitro study.Scientific reports · 2024Article
- Anti-biofilm activity of 445 nm and 970 nm diode laser on mixed species colonies of- aggregatibacter actinomycetemcomitans and porphyromonas gingivalis cultured on titanium discs -an in vitro study.Lasers in medical science · 2024Article
- Article
- Conventional vs. diode laser stapedotomy: audiological outcomes and clinical safety.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Observational
- Thermal Effects on Dental Pulp during Laser-Assisted Bleaching Procedures with Diode Lasers in a Clinical Study.Journal of clinical medicine · 2024Article
- Article
- Temperature changes in the pulp chamber and bleaching gel during tooth bleaching assisted by diode laser (445 nm) using different power settings.Lasers in medical science · 2023Article
- SEM Evaluation of Thermal Effects Produced by a 445 nm Laser on Implant Surfaces.Dentistry journal · 2023Article
- Use of lasers in gastrointestinal endoscopy: a review of the literature.Lasers in medical science · 2023Review
- Treatment of Gingival Growth Due to Amlodipine Use With a 445-nm Diode Laser: A Case Report.Cureus · 2022Article
- Use of Blue and Blue-Violet Lasers in Dentistry: A Narrative Review.Journal of lasers in medical sciences · 2021Review
- A Single Case Report of Granular Cell Tumor of the Tongue Successfully Treated through 445 nm Diode Laser.Healthcare (Basel, Switzerland) · 2020Article
- Histological Effects of an Innovative 445 Nm Blue Laser During Oral Soft Tissue Biopsy.International journal of environmental research and public health · 2020Article
- Assessment of the Photobiomodulation Effect of a Blue Diode Laser on the Proliferation and Migration of Cultured Human Gingival Fibroblast Cells: A PreliminaryJournal of lasers in medical sciences · 2020Article
- Effectiveness of photopolymerization in composite resins using a novel 445-nm diode laser in comparison to LED and halogen bulb technology.Lasers in medical science · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe objective of this study was to examine a new blue light diode laser system (445 nm) for dental soft tissue surgery on cellular level. MATERIALS AND
methodsAn in vitro cell culture model was established to evaluate the effects of the 445-nm diode laser in comparison to an established infrared diode laser (IR). Monolayer cell cultures were irradiated and wound healing was morphometrically measured. Fluorescence staining was used for proof of potential DNA double-strand breaks as well as cytoskeleton alterations. Cellular live/dead discrimination was performed and temperature development during laser irradiation was measured with a thermographic infrared camera.
resultsA characteristic zone formation was detected after irradiation with both wavelengths. Despite a larger wound area after irradiation with 445 nm, due to its higher temperature development, this laser system showed a faster wound healing in comparison to the IR laser. No increase of devitalized cells was documented with higher distances between laser tip and cell layer and thus without thermal interaction. Neither cytoskeleton alteration nor DNA double-strand breaks could be recorded after irradiation in non-contact mode.
conclusionsThe blue diode laser system demonstrated an excellent direct thermal coupling to cells and tissues without side effects even by reduced power settings. CLINICAL RELEVANCE: The blue diode laser seems to be a promising technology for clinical application due to high absorption of blue light without major side effects in adjacent tissues even by reduced power settings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.