ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2016
Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Novel 3-Methoxypropanamide Derivatives as Potential Antiseizure and Antinociceptive Agents: Experimental Evidence from In Vitro and In Vivo Studies.Journal of medicinal chemistry · 2026Article
- Critical role of the mast cell/tryptase/PAR2 axis in anastrozole-induced pain.British journal of pharmacology · 2026Article
- Article
- Protease Activated Receptors and Arthritis.International journal of molecular sciences · 2021Review
- Capsaicin-Sensitive Peptidergic Sensory Nerves Are Anti-Inflammatory Gatekeepers in the Hyperacute Phase of a Mouse Rheumatoid Arthritis Model.International journal of molecular sciences · 2021Article
- Anti-Inflammatory and Analgesic Effects of TRPV1 Polypeptide Modulator APHC3 in Models of Osteo- and Rheumatoid Arthritis.Marine drugs · 2021Article
- Involvement of Mast Cells in the Pathophysiology of Pain.Frontiers in cellular neuroscience · 2021Article
- Topical Diclofenac, an Efficacious Treatment for Osteoarthritis: A Narrative Review.Rheumatology and therapy · 2020Review
- Hemokinin-1 as a Mediator ofFrontiers in pharmacology · 2020Article
- Regulatory role of capsaicin-sensitive peptidergic sensory nerves in the proteoglycan-induced autoimmune arthritis model of the mouse.Journal of neuroinflammation · 2018Article
- Complex Role of Capsaicin-Sensitive Afferents in the Collagen Antibody-Induced Autoimmune Arthritis of the Mouse.Scientific reports · 2018Article
- Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis.Pharmaceuticals (Basel, Switzerland) · 2018Review
- The Neurokinin-1 Receptor Contributes to the Early Phase of Lipopolysaccharide-Induced FeverFrontiers in immunology · 2018Article
- Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study.Arthritis research & therapy · 2017Article
- Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse.Scientific reports · 2017Article
- Article
- Skin inflammatory reactions to capsaicin in rheumatoid arthritis patients compared to healthy controls.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE,
designMast cell tryptase (MCT) is elevated in arthritic joints, but its direct effects are not known. Here, we investigated MCT-evoked acute inflammatory and nociceptive mechanisms with behavioural, in vivo imaging and immunological techniques. MATERIAL AND SUBJECTS: Neurogenic inflammation involving capsaicin-sensitive afferents, transient receptor potential vanilloid 1 receptor (TRPV1), substance P (SP), neurokinin A (NKA) and their NK1 tachykinin receptor were studied using gene-deleted mice compared to C57Bl/6 wildtypes (n = 5-8/group). TREATMENT: MCT was administered intraarticularly or topically (20 μl, 12 μg/ml). Capsaicin-sensitive afferents were defunctionalized with the TRPV1 agonist resiniferatoxin (RTX; 30-70-100 μg/kg s.c. pretreatment).
methodsKnee diameter was measured with a caliper, synovial perfusion with laser Doppler imaging, mechanonociception with aesthesiometry and weight distribution with incapacitance tester over 6 h. Cytokines and neuropeptides were determined with immunoassays.
resultsMCT induced synovial vasodilatation, oedema, impaired weight distribution and mechanical hyperalgesia, but cytokine or neuropeptide levels were not altered at the 6-h timepoint. Hyperaemia was reduced in RTX-treated and TRPV1-deleted animals, and oedema was absent in NK1-deficient mice. Hyperalgesia was decreased in SP/NKA- and NK1-deficient mice, weight bearing impairment in RTX-pretreated, TRPV1- and NK1-deficient animals.
conclusionsMCT evokes synovial hyperaemia, oedema, hyperalgesia and spontaneous pain. Capsaicin-sensitive afferents and TRPV1 receptors are essential for vasodilatation, while tachykinins mediate oedema and pain.
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