Evidence map›Paper›PMID 27251160›Full record

ArticleIn vitro cellular & developmental biology. Animal2016

TNF-alpha and Notch signaling regulates the expression of HOXB4 and GATA3 during early T lymphopoiesis.

Josiane Lilian Dos Santos Schiavinato, Lucila Habib Bourguignon Oliveira, Amélia Goes Araujo, Maristela Delgado Orellana, Patrícia Viana Bonini de Palma, Dimas Tadeu Covas, Marco Antonio Zago, Rodrigo Alexandre Panepucci

Abstract read
PubMed Publisher
In one paragraph

Article in In vitro cellular & developmental biology. Animal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. The Role of Shed PrPJournal of immunology (Baltimore, Md. : 1950) · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Josiane Lilian Dos Santos SchiavinatoDepartment of Genetics, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. josililian@gmail.com.
Lucila Habib Bourguignon OliveiraNational Institute of Science and Technology in Stem Cell and for Cell Therapy (INCTC) Center for Cell Therapy (CTC) and Regional Blood Center, Ribeirão Preto, SP, Brazil.
Amélia Goes AraujoMedical School of Ribeirão Preto, University of São Paulo , Ribeirão Preto, São Paulo, Brazil.
Maristela Delgado OrellanaNational Institute of Science and Technology in Stem Cell and for Cell Therapy (INCTC) Center for Cell Therapy (CTC) and Regional Blood Center, Ribeirão Preto, SP, Brazil.
Patrícia Viana Bonini de PalmaNational Institute of Science and Technology in Stem Cell and for Cell Therapy (INCTC) Center for Cell Therapy (CTC) and Regional Blood Center, Ribeirão Preto, SP, Brazil.
Dimas Tadeu CovasNational Institute of Science and Technology in Stem Cell and for Cell Therapy (INCTC) Center for Cell Therapy (CTC) and Regional Blood Center, Ribeirão Preto, SP, Brazil.
Marco Antonio ZagoNational Institute of Science and Technology in Stem Cell and for Cell Therapy (INCTC) Center for Cell Therapy (CTC) and Regional Blood Center, Ribeirão Preto, SP, Brazil.
Rodrigo Alexandre PanepucciDepartment of Genetics, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the early thymus colonization, Notch signaling activation on hematopoietic progenitor cells (HPCs) drives proliferation and T cell commitment. Although these processes are driven by transcription factors such as HOXB4 and GATA3, there is no evidence that Notch directly regulates their transcription. To evaluate the role of NOTCH and TNF signaling in this process, human CD34

Indexed as

LymphopoiesisSignal TransductionAnimalsBasic Helix-Loop-Helix ProteinsCell Cycle ProteinsCell LineCell LineageGATA3 Transcription FactorGene Expression RegulationHomeodomain ProteinsHumansMiceNF-kappa BProtein SubunitsReceptors, NotchT-LymphocytesBasic Helix-Loop-Helix ProteinsCell Cycle ProteinsGATA3 protein, humanGATA3 Transcription FactorHES1 protein, humanHEY1 protein, humanHomeodomain ProteinsHOXB4 protein, humanNF-kappa BProtein SubunitsReceptors, NotchTranscription Factor HES-1Transcription FactorsTumor Necrosis Factor-alphaCD34Hematopoietic stem cellsHOXB4 and GATA3Notch signaling

Identifiers

PMID27251160
OpenAlexW2474037981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.