Evidence map›Paper›PMID 27251079›Full record

ArticleJournal of human hypertension2016

The reduction in circulating levels of melatonin may be associated with the development of preeclampsia.

K Zeng, Y Gao, J Wan, M Tong, A C Lee, M Zhao, Q Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of human hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

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  16. Melatonin for the Management of Preeclampsia: A Review.Antioxidants (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

K ZengDepartment of Surgeon, Wuxi No 2 People' Hospital, Nanjing Medical University, Wuxi, China.
Y GaoDepartment of Obstetrics, Hospital of Obstetrics and Gynaecology, Fudan University, Shanghai, China.
J WanDepartment of Pathology, Wuxi No 2 People' Hospital, Nanjing Medical University, Wuxi, China.
M TongDepartment of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand.
A C LeeDepartment of Obstetrics, Section of Epidemiology and Biostatistics, School of Population Health, University of Auckland, Auckland, New Zealand.
M ZhaoWuxi Maternity and Children Health Hospital, Nanjing Medical University, Wuxi, China.
Q ChenDepartment of Obstetrics, Hospital of Obstetrics and Gynaecology, Fudan University, Shanghai, China.
University of Auckland · NZWuxi No.2 People's Hospital · CNNanjing Medical University · CNObstetrics and Gynecology Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Placental dysfunction and oxidative stress contribute to the pathogenesis of preeclampsia, which is a pregnancy-specific disorder. It has been suggested that the incidence of preeclampsia has a seasonal variation. Melatonin, as a seasonal factor, has been suggested to be involved in a successful pregnancy. In this study, we investigated the association of circulating levels of melatonin with preeclampsia. Serum was collected from women with preeclampsia (n=113) and gestation-matched healthy pregnant women, and the levels of melatonin were measured. In addition, the expression of melatonin receptors was examined in preeclamptic placentae (n=27). The association of the incidence of preeclampsia and seasonal variation was also analysed from 1491 women with preeclampsia within 77 745 healthy pregnancies. The serum levels of melatonin were significantly reduced in women with preeclampsia at presentation and these reduced serum levels of melatonin were not associated with the severity or time onset of preeclampsia nor with seasonal variation. The expression of melatonin receptor, MT1 was reduced in preeclamptic placentae. The incidence of preeclampsia was did exhibit seasonal variation, but this was largely due to the increase in the incidence of mild or late-onset preeclampsia. Our results demonstrate that reduced melatonin levels are associated with the development of preeclampsia but that the circulating levels of melatonin do not appear to be subject to seasonal variation during pregnancy.

Indexed as

BiomarkersChinaDown-RegulationFemaleHospitals, TeachingHumansIncidenceMelatoninPlacentaPre-EclampsiaPregnancyReceptor, Melatonin, MT1Retrospective StudiesRisk FactorsSeasonsBiomarkersMelatoninReceptor, Melatonin, MT1

Identifiers

PMID27251079
OpenAlexW2417748579

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.