Evidence map›Paper›PMID 27251077›Full record

ArticleJournal of biomedical optics2016

Diffuse optical microscopy for quantification of depth-dependent epithelial backscattering in the cervix.

Nico Bodenschatz, Sylvia Lam, Anita Carraro, Jagoda Korbelik, Dianne M Miller, Jessica N McAlpine, Marette Lee, Alwin Kienle, Calum MacAulay

Open access · hybridAbstract read
In one paragraph

Article in Journal of biomedical optics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review of structured light in diffuse optical imaging.Journal of biomedical optics · 2018
    Review
  4. Article
  5. Real-time endoscopic optical properties imaging.Biomedical optics express · 2017
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Nico BodenschatzInstitut für Lasertechnologien in der Medizin und Meßtechnik, Helmholtzstr. 12, D-89081 Ulm, GermanybBritish Columbia Cancer Research Centre, Cancer Imaging Department, 675 West 10th Avenue, Vancouver, BC V5Z 1L3, Canada.
Sylvia LamBritish Columbia Cancer Research Centre, Cancer Imaging Department, 675 West 10th Avenue, Vancouver, BC V5Z 1L3, Canada.
Anita CarraroBritish Columbia Cancer Research Centre, Cancer Imaging Department, 675 West 10th Avenue, Vancouver, BC V5Z 1L3, Canada.
Jagoda KorbelikBritish Columbia Cancer Research Centre, Cancer Imaging Department, 675 West 10th Avenue, Vancouver, BC V5Z 1L3, Canada.
Dianne M MillerUniversity of British Columbia, Division of Gynaecologic Oncology, 2775 Laurel Street, Vancouver, BC V5Z 1M9, Canada.
Jessica N McAlpineUniversity of British Columbia, Division of Gynaecologic Oncology, 2775 Laurel Street, Vancouver, BC V5Z 1M9, Canada.
Marette LeeUniversity of British Columbia, Division of Gynaecologic Oncology, 2775 Laurel Street, Vancouver, BC V5Z 1M9, Canada.
Alwin KienleInstitut für Lasertechnologien in der Medizin und Meßtechnik, Helmholtzstr. 12, D-89081 Ulm, Germany.
Calum MacAulayBritish Columbia Cancer Research Centre, Cancer Imaging Department, 675 West 10th Avenue, Vancouver, BC V5Z 1L3, Canada.
University of British Columbia · CAInstitute for Laser Technology in Medicine and Measurement Technique · DEOccupational Cancer Research Centre · CA

Funding

Technical FeasibilityP01CA082710 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GUILLAUD, MARTIAL · 1999 to 2014
$28.7M
NCI NIH HHS P01 CA082710
6 · The paper itself

Abstract

A fiber optic imaging approach is presented using structured illumination for quantification of almost pure epithelial backscattering. We employ multiple spatially modulated projection patterns and camera-based reflectance capture to image depth-dependent epithelial scattering. The potential diagnostic value of our approach is investigated on cervical ex vivo tissue specimens. Our study indicates a strong backscattering increase in the upper part of the cervical epithelium caused by dysplastic microstructural changes. Quantization of relative depth-dependent backscattering is confirmed as a potentially useful diagnostic feature for detection of precancerous lesions in cervical squamous epithelium.

Indexed as

Cervix UteriDiagnostic ImagingEpitheliumFemaleHumansMicroscopyOptical ImagingUterine Cervical Neoplasms

Identifiers

PMID27251077
PMCPMC8357336
OpenAlexW2413731657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.