ArticleNature plants2016
Specific control of Arabidopsis BAK1/SERK4-regulated cell death by protein glycosylation.
Article in Nature plants, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.
- A Meta-Analysis Reveals Opposite Effects of Biotic and Abiotic Stresses on Transcript Levels of Arabidopsis Intracellular Immune Receptor Genes.Frontiers in plant science · 2021Pooled it
- VqLecRKV.4 and VqBAK1 Modulate Grapevine Resistance to Powdery Mildew by Regulating Dynamic Balance of ROS.Plant biotechnology journal · 2026Article
- De-repression of protein phosphatase 5 by the chaperone organizer HOP1 activates plant NLR immunity.Nature plants · 2026Article
- Phytosulfokine signalling blocks mycotoxin toxicity in Arabidopsis and mediates suppression of cell death activated by bacterial microbe-associated molecular patterns.The New phytologist · 2026Article
- Genetic Diversity, Predictive Protein Structures, and Interaction Networks of Cysteine-Rich Receptor-Like Kinases inComputational and structural biotechnology journal · 2026Article
- Virus-Induced Gene Silencing for Identifying Autoimmune Regulators in Arabidopsis.Methods in molecular biology (Clifton, N.J.) · 2026Article
- SERK5 genetically compensates for the loss of BAK1 and BKK1 in regulating elf18-triggered immune signaling inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Role of Methyl thiobutyrate toFrontiers in plant science · 2025Article
- The antagonistic role of an E3 ligase pair in regulating plant NLR-mediated autoimmunity and fungal pathogen resistance.Cell host & microbe · 2024Article
- Analysis of Protein Glycosylation in the ER.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A large-scale screening identifies receptor-like kinases with common features in kinase domains that are potentially related to disease resistance in planta.Frontiers in plant science · 2024Article
- Genome-Wide Investigation and Expression Analysis of the Catalase Gene Family in Oat Plants (Plants (Basel, Switzerland) · 2023Article
- Screening of microRNAs and target genes involved in Sclerotinia sclerotiorum (Lib.) infection in Brassica napus L.BMC plant biology · 2023Article
- BAK-up: the receptor kinase BAK-TO-LIFE 2 enhances immunity when BAK1 is lacking.Stress biology · 2023Article
- Article
- Functional and evolutionary study of MLO gene family in the regulation of Sclerotinia stem rot resistance in Brassica napus L.Biotechnology for biofuels and bioproducts · 2023Article
- A necessary considering factor for breeding: growth-defense tradeoff in plants.Stress biology · 2023Review
- Review
- Genome and Transcriptome Sequencing Analysis of FusariumMicrobiology spectrum · 2022Article
- The Rice Malectin Regulates Plant Cell Death and Disease Resistance by Participating in Glycoprotein Quality Control.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
Abstract
Precise control of cell death is essential for the survival of all organisms. Arabidopsis thaliana BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 (BAK1) and somatic embryogenesis receptor kinase 4 (SERK4) redundantly and negatively regulate cell death through elusive mechanisms. By deploying a genetic screen for suppressors of cell death triggered by virus-induced gene silencing of BAK1/SERK4 on Arabidopsis knockout collections, we identified STT3a, a protein involved in N-glycosylation modification, as an important regulator of bak1/serk4 cell death. Systematic investigation of glycosylation pathway and endoplasmic reticulum (ER) quality control (ERQC) components revealed distinct and overlapping mechanisms of cell death regulated by BAK1/SERK4 and their interacting protein BIR1. Genome-wide transcriptional analysis revealed the activation of members of cysteine-rich receptor-like kinase (CRK) genes in the bak1/serk4 mutant. Ectopic expression of CRK4 induced STT3a/N-glycosylation-dependent cell death in Arabidopsis and Nicotiana benthamiana. Therefore, N-glycosylation and specific ERQC components are essential to activate bak1/serk4 cell death, and CRK4 is likely to be among client proteins of protein glycosylation involved in BAK1/SERK4-regulated cell death.
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Registered trials
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