ArticleMovement disorders : official journal of the Movement Disorder Society2016
Subliminal gait initiation deficits in rapid eye movement sleep behavior disorder: A harbinger of freezing of gait?
Article in Movement disorders : official journal of the Movement Disorder Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Motor features that distinguish isolated REM sleep behavior disorder patients from healthy controls: A systematic review.Journal of Parkinson's disease · 2025Pooled it
- Early detection of diseases causing dementia using digital navigation and gait measures: A systematic review of evidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Real-world gait changes preceding Parkinson's disease diagnosis in a population-scale UK biobank cohort.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Association of wearable sensor-based gait analysis with phenoconversion trajectories in idiopathic REM sleep behavior disorder.NPJ Parkinson's disease · 2026Article
- Accelerated Progression of Gait Impairment in Parkinson's Disease and REM Sleep Without Atonia.Annals of clinical and translational neurology · 2026Article
- Clinical translation of fluid, imaging, and digital biomarkers for Alzheimer's disease.Alzheimer's research & therapy · 2026Review
- Surface electromyographic profiles during gait initiation in people with Parkinson's disease: The effects of external sensory cueing.Journal of Parkinson's disease · 2025Article
- Contemporary diagnostic visual and automated polysomnographic REM sleep without atonia thresholds in isolated REM sleep behavior disorder.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Gait Analysis with Wearable Sensors in Isolated REM Sleep Behavior Disorder Associated with Phenoconversion: An Explorative Study.Journal of Parkinson's disease · 2024Article
- Neuropathology of incidental Lewy body & prodromal Parkinson's disease.Molecular neurodegeneration · 2023Review
- Current approaches to characterize micro- and macroscale circuit mechanisms of Parkinson's disease in rodent models.Experimental neurology · 2022Review
- Disrupted functional connectivity in PD with probable RBD and its cognitive correlates.Scientific reports · 2021Article
- Clinical features and related factors of freezing of gait in patients with Parkinson's disease.Brain and behavior · 2021Article
- Motor Dysfunction in REM Sleep Behavior Disorder: A Rehabilitation Framework for Prodromal Synucleinopathy.Neurorehabilitation and neural repair · 2021Review
- REM Sleep Without Atonia and Gait Impairment in People with Mild-to-Moderate Parkinson's Disease.Journal of Parkinson's disease · 2021Article
- Detection of Motor Dysfunction With Wearable Sensors in Patients With Idiopathic Rapid Eye Movement Disorder.Frontiers in bioengineering and biotechnology · 2021Article
- The Relationship of Rapid Eye Movement Sleep Behavior Disorder and Freezing of Gait in Parkinson's Disease.Cureus · 2020Review
- Clinical trials in REM sleep behavioural disorder: challenges and opportunities.Journal of neurology, neurosurgery, and psychiatry · 2020Review
- Neural Correlates of Freezing of Gait in Parkinson's Disease: An Electrophysiology Mini-Review.Frontiers in neurology · 2020Review
- Freezing of gait in Parkinson's disease: pathophysiology, risk factors and treatments.Translational neurodegeneration · 2020Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMuscle activity during rapid eye movement sleep is markedly increased in people with rapid eye movement sleep behavior disorder and people with Parkinson's disease (PD) who have freezing of gait. This study examined whether individuals with rapid eye movement sleep behavior disorder who do not have a diagnosis of PD show abnormalities in gait initiation that resemble the impairments observed in PD and whether there is a relationship between these deficits and the level of rapid eye movement sleep without atonia.
methodsGait initiation and polysomnography studies were conducted in 4 groups of 10 participants: rapid eye movement sleep behavior disorder, PD with and without freezing of gait, and controls.
resultsSignificant reductions were seen in the posterior shift of the center of pressure during the propulsive phase of gait initiation in the groups with rapid eye movement sleep behavior disorder and PD with freezing of gait when compared with controls and PD nonfreezers. These reductions negatively correlated with the amount of rapid eye movement sleep without atonia. The duration of the initial dorsiflexor muscle burst during gait initiation was significantly reduced in both PD groups and the rapid eye movement sleep behavior disorder cohort.
conclusionsThese results provide evidence that people with rapid eye movement sleep behavior disorder, prior to a diagnosis of a degenerative neurologic disorder, show alterations in the coupling of posture and gait similar to those seen in PD. The correlation between increased rapid eye movement sleep without atonia and deficits in forward propulsion during the push-off phase of gait initiation suggests that abnormities in the regulation of muscle tone during rapid eye movement sleep may be related to the pathogenesis of freezing of gait. © 2016 International Parkinson and Movement Disorder Society.
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