Evidence map›Paper›PMID 27250856›Full record

ArticleGigaScience2016

Genomic resources and draft assemblies of the human and porcine varieties of scabies mites, Sarcoptes scabiei var. hominis and var. suis.

Ehtesham Mofiz, Deborah C Holt, Torsten Seemann, Bart J Currie, Katja Fischer, Anthony T Papenfuss

Open access · goldAbstract read
In one paragraph

Article in GigaScience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 39 citations in OpenAlex.

  1. Scabies.Nature reviews. Disease primers · 2024
    Review
  2. Assembly of a Draft Genome for the Mouse EctoparasiteJournal of the American Association for Laboratory Animal Science : JAALAS · 2023
    Article
  3. Human follicular mites: Ectoparasites becoming symbionts.Molecular biology and evolution · 2022
    Article
  4. Zoonotic Episodes of Scabies: A Global Overview.Pathogens (Basel, Switzerland) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Ehtesham MofizBioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Deborah C HoltMenzies School of Health Research, Charles Darwin University, Casuarina, NT, 0811, Australia.
Torsten SeemannVictorian Life Sciences Computation Initiative, University of Melbourne, Melbourne, VIC, 3010, Australia.
Bart J CurrieMenzies School of Health Research, Charles Darwin University, Casuarina, NT, 0811, Australia.
Katja FischerQIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD, 4006, Australia.
Anthony T PapenfussBioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia. papenfuss@wehi.edu.au.
Walter and Eliza Hall Institute of Medical Research · AUCharles Darwin University · AUMenzies School of Health Research · AUQIMR Berghofer Medical Research Institute · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe scabies mite, Sarcoptes scabiei, is a parasitic arachnid and cause of the infectious skin disease scabies in humans and mange in other animal species. Scabies infections are a major health problem, particularly in remote Indigenous communities in Australia, where secondary group A streptococcal and Staphylococcus aureus infections of scabies sores are thought to drive the high rate of rheumatic heart disease and chronic kidney disease.

resultsWe sequenced the genome of two samples of Sarcoptes scabiei var. hominis obtained from unrelated patients with crusted scabies located in different parts of northern Australia using the Illumina HiSeq. We also sequenced samples of Sarcoptes scabiei var. suis from a pig model. Because of the small size of the scabies mite, these data are derived from pools of thousands of mites and are metagenomic, including host and microbiome DNA. We performed cleaning and de novo assembly and present Sarcoptes scabiei var. hominis and var. suis draft reference genomes. We have constructed a preliminary annotation of this reference comprising 13,226 putative coding sequences based on sequence similarity to known proteins.

conclusionsWe have developed extensive genomic resources for the scabies mite, including reference genomes and a preliminary annotation.

Indexed as

AnimalsAustraliaGenomeHigh-Throughput Nucleotide SequencingHumansMetagenomicsMicrobiotaSarcoptes scabieiScabiesSequence Analysis, DNASwineSwine DiseasesIndigenous Australian healthSarcoptes scabiei var. hominisSarcoptes scabiei var. suisScabies mite

Identifiers

PMID27250856
PMCPMC4890329
OpenAlexW2403550572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.