Evidence map›Paper›PMID 27250723›Full record

ArticleJournal of cardiovascular translational research2016

A Multidisciplinary Assessment of Remote Myocardial Fibrosis After Reperfused Myocardial Infarction in Swine and Patients.

Arantxa Hervas, Amparo Ruiz-Sauri, Jose Gavara, Jose V Monmeneu, Elena de Dios, Cesar Rios-Navarro, Nerea Perez-Sole, Itziar Perez, Daniel Monleon, Jose M Morales and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Cardiac fibrosis.Cardiovascular research · 2021
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Arantxa HervasCardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
Amparo Ruiz-SauriPathology Department, School of Medicine, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain. amparo.ruiz-sauri@uv.es.
Jose GavaraCardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
Jose V MonmeneuERESA, Valencia, Spain.
Elena de DiosCardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
Cesar Rios-NavarroCardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
Nerea Perez-SoleCardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
Itziar PerezCBIT, Polytechnic University of Valencia, Valencia, Spain.
Daniel MonleonLaboratory of Metabolomics, University of Valencia, INCLIVA, Valencia, Spain.
Jose M MoralesLaboratory of Metabolomics, University of Valencia, INCLIVA, Valencia, Spain.
Gema MinanaCardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
Julio NunezCardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
Clara BonanadCardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
Ana DiazSCSIE, Universidad de Valencia, Valencia, Spain.
Jose M VilaPhysiology Department, School of Medicine, University of Valencia, Valencia, Spain.
Francisco J ChorroCardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
Vicente BodiCardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain. vicente.bodi@uv.es.
Universitat de València · ESHospital Clínico Universitario de Valencia · ESEndesa (Spain) · ESUniversitat Politècnica de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In extensive nonreperfused myocardial infarction (MI), remote fibrosis has been documented. Early reperfusion by primary angioplasty represents the gold standard method to minimize the extension of the infarction. We aimed to ascertain whether fibrosis also affects remote regions in reperfused MI in swine and patients. Swine were subjected to a transient occlusion of the left anterior descending artery followed by 1-week or 1-month reperfusion. Collagen content in the remote area macroscopically, microscopically, by magnetic resonance microimaging, and at the molecular level was similar to controls. In patients with previous MI, samples from autopsies displayed a significant increase in collagen content only in the infarct region. In patients with previous MI submitted to cardiac magnetic resonance-T1 mapping, the extracellular volume fraction in remote segments was similar to that for controls. In all scenarios, the remote region did not show a significant increase of collagen content in comparison with controls.

Indexed as

Percutaneous Coronary InterventionAgedAged, 80 and overAnimalsAutopsyCase-Control StudiesCollagenDisease Models, AnimalFemaleFibrosisHumansMagnetic Resonance ImagingMaleMicroscopy, Electron, TransmissionMiddle AgedMyocardial InfarctionCollagenMyocardial infarctionRemote fibrosisReperfusionSwine model

Identifiers

PMID27250723
OpenAlexW2408918334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.