ReviewJournal of natural medicines2016
Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites.
Review in Journal of natural medicines, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
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- Characterization of an (E, E)-farnesyl pyrophosphate synthase in Saxifraga stolonifera involved in triterpenoid biosynthesis.Plant molecular biology · 2026Article
- Differential effects of biologically and chemically synthesized copper oxide nanoparticles on artemisinin biosynthesis gene expression in Artemisia absinthium.Scientific reports · 2026Article
- Bacterial Membrane Vesicles for In Vitro Catalysis.Bioengineering (Basel, Switzerland) · 2023Review
- Ethnomedicinal plants used for malaria treatment in Rukungiri District, Western Uganda.Tropical medicine and health · 2023Article
- Medicinal plants used for treatment of malaria by indigenous communities of Tororo District, Eastern Uganda.Tropical medicine and health · 2023Article
- Dihydroartemisinin imposes positive and negative regulation on Treg and plasma cells via direct interaction and activation of c-Fos.Communications biology · 2023Article
- Molecular insights into the genetic diversity and population structure ofRevista brasileira de botanica : Brazilian journal of botany · 2023Article
- Aging affects artemisinin synthesis in Artemisia annua.Scientific reports · 2021Article
- Research Advances on Health Effects of EdibleFoods (Basel, Switzerland) · 2020Review
- Nanoparticles Formulations of Artemisinin and Derivatives as Potential Therapeutics for the Treatment of Cancer, Leishmaniasis and Malaria.Pharmaceutics · 2020Review
- Transformation of Amorphadiene Synthase and Antisilencing P19 Genes intoAdvanced pharmaceutical bulletin · 2020Article
- Antibacterial strategies inspired by the oxidative stress and response networks.Journal of microbiology (Seoul, Korea) · 2019Review
- Archangelolide: A sesquiterpene lactone with immunobiological potential fromBeilstein journal of organic chemistry · 2019Article
- AaABF3, an Abscisic Acid-Responsive Transcription Factor, Positively Regulates Artemisinin Biosynthesis inFrontiers in plant science · 2018Article
- Semisynthesis, an Anti-Inflammatory Effect of Derivatives of 1β-Hydroxy Alantolactone from Inula britannica.Molecules (Basel, Switzerland) · 2017Article
- Elimination of Schistosoma mansoni in infected mice by slow release of artemisone.International journal for parasitology. Drugs and drug resistance · 2017Article
- A Review of Biotechnological Artemisinin Production in Plants.Frontiers in plant science · 2017Review
- Hairless but no longer clueless: understanding glandular trichome development.Journal of experimental botany · 2016Article
- Alternative first-line malaria treatment.Annals of African medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malaria is a worldwide disease caused by Plasmodium parasites. A sesquiterpene endoperoxide artemisinin isolated from Artemisia annua was discovered and has been accepted for its use in artemisinin-based combinatorial therapies, as the most effective current antimalarial treatment. However, the quantity of this compound produced from the A. annua plant is very low, and the availability of artemisinin is insufficient to treat all infected patients. In addition, the emergence of artemisinin-resistant Plasmodium has been reported recently. Several techniques have been applied to enhance artemisinin availability, and studies related to its mode of action and the mechanism of resistance of malaria-causing parasites are ongoing. In this review, we summarize the application of modern technologies to improve the production of artemisinin, including our ongoing research on artemisinin biosynthetic genes in other Artemisia species. The current understanding of the mode of action of artemisinin as well as the mechanism of resistance against this compound in Plasmodium parasites is also presented. Finally, the current situation of malaria infection and the future direction of antimalarial drug development are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.