Evidence map›Paper›PMID 27250345›Full record

ReviewInternational journal of hematology2016

Regulation of hematopoietic development by ZBTB transcription factors.

Takahiro Maeda

Erratum issuedOpen access · greenAbstract readReview
In one paragraph

Review in International journal of hematology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 80 citations in OpenAlex.

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  20. The N-Terminal Part ofInternational journal of molecular sciences · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Takahiro MaedaDivision of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, One Blackfan Circle, Boston, MA, 02115, USA. tmaeda@partners.org.
Brigham and Women's Hospital · US

Funding

Targeting the transcription machinery for fetal globin inductionR56DK105001 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI MAEDA, TAKAHIRO · 2015 to 2015
$142k
NIDDK NIH HHS R56 DK105001
6 · The paper itself

Abstract

Hematopoietic development is governed by the coordinated expression of lineage- and differentiation stage-specific genes. Transcription factors play major roles in this process and their perturbation may underlie hematologic and immunologic disorders. Nearly 1900 transcription factors are encoded in the human genome: of these, 49 BTB (for broad-complex, tram-track and bric à brac)-zinc finger transcription factors referred to as ZBTB or POK proteins have been identified. ZBTB proteins, including BCL6, PLZF, ThPOK and LRF, exhibit a broad spectrum of functions in normal and malignant hematopoiesis. This review summarizes developmental and molecular functions of ZBTB proteins relevant to hematology.

Indexed as

Hematologic DiseasesHematopoiesisHumansRepressor ProteinsTranscription FactorsZinc FingersRepressor ProteinsTranscription FactorsZBTB1 protein, humanCo-repressorHematopoiesisTranscription factor

Identifiers

PMID27250345
PMCPMC5001899
OpenAlexW2417831361

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.