Evidence map›Paper›PMID 27250199›Full record

ArticleThe Journal of the Acoustical Society of America2016

Size-isolation of ultrasound-mediated phase change perfluorocarbon droplets using differential centrifugation.

Karla P Mercado, Kirthi Radhakrishnan, Kyle Stewart, Lindsay Snider, Devin Ryan, Kevin J Haworth

Abstract read
In one paragraph

Article in The Journal of the Acoustical Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Ultrasound-responsive composite hydrogels: Design rules for spatiotemporally controlled drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Review
  2. Article
  3. Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Acoustic vaporization threshold of lipid-coated perfluoropentane droplets.The Journal of the Acoustical Society of America · 2018
    Article
  12. Article
  13. Dissolved Oxygen Scavenging by Acoustic Droplet Vaporization using Intravascular Ultrasound.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karla P MercadoDepartment of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA.
Kirthi RadhakrishnanDepartment of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA.
Kyle StewartBiomedical Engineering Program, University of Cincinnati, Cincinnati, Ohio 45267, USA.
Lindsay SniderBiomedical Engineering Program, University of Cincinnati, Cincinnati, Ohio 45267, USA.
Devin RyanDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, USA karlapatricia.mercado@uc.edu, kirthi.radhakrishnan@gmail.com, stewake@mail.uc.edu, sniderlm@mail.uc.edu, devin.ryan514@gmail.com, kevin.haworth@uc.edu.
Kevin J HaworthDepartment of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA.

Funding

KL2 Training ProgramKL2TR001426 · NCATS · UNIVERSITY OF CINCINNATI · PI ZELLER, MARGARET H · 2015 to 2024
$6.8M
NCATS NIH HHS KL2 TR001426
6 · The paper itself

Abstract

Perfluorocarbon droplets that are capable of an ultrasound-mediated phase transition have applications in diagnostic and therapeutic ultrasound. Techniques to modify the droplet size distribution are of interest because of the size-dependent acoustic response of the droplets. Differential centrifugation has been used to isolate specific sizes of microbubbles. In this work, differential centrifugation was employed to isolate droplets with diameters between 1 and 3 μm and 2 and 5 μm from an initially polydisperse distribution. Further, an empirical model was developed for predicting the droplet size distribution following differential centrifugation and to facilitate the selection of centrifugation parameters for obtaining desired size distributions.

Indexed as

CentrifugationFluorocarbonsModels, TheoreticalParticle SizePentanesPhase TransitionUltrasonicsFluorocarbonsPentanesperfluoropentane

Identifiers

PMID27250199
PMCPMC5848830

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.