ArticleActa veterinaria Scandinavica2016
Progression of experimental chronic Aleutian mink disease virus infection.
Article in Acta veterinaria Scandinavica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Pathogenesis of Aleutian Mink Disease Virus Infection-Comparison of Natural Transmission with Experimental Aerosol and Intraperitoneal Inoculation.Pathogens (Basel, Switzerland) · 2026Article
- Identifying selection signatures for immune response and resilience to Aleutian disease in mink using genotype data.Frontiers in genetics · 2024Article
- Review
- Prevalence of red panda amdoparvovirus infection in European zoos.Frontiers in veterinary science · 2023Article
- Genetic and phenotypic correlations between Aleutian disease tests with body weight, growth, and feed efficiency traits in mink.Journal of animal science · 2022Article
- Serum Analytes of American Mink (Neovison Vison) Challenged with Aleutian Mink Disease Virus.Animals : an open access journal from MDPI · 2022Article
- Applying Machine Learning Algorithms for the Classification of Mink Infected with Aleutian Disease Using Different Data Sources.Animals : an open access journal from MDPI · 2022Article
- AMDV Vaccine: Challenges and Perspectives.Viruses · 2021Review
- Aleutian mink disease: Spatio-temporal variation of prevalence and influence on the feral American mink.Transboundary and emerging diseases · 2021Article
- Detection of selection signatures for response to Aleutian mink disease virus infection in American mink.Scientific reports · 2021Article
- Article
- Dose response of black American mink to Aleutian mink disease virus.Immunity, inflammation and disease · 2020Article
- A comparative molecular characterization of AMDV strains isolated from cases of clinical and subclinical infection.Virus genes · 2018Article
- Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAleutian mink disease virus (AMDV) is found world-wide and has a major impact on mink health and welfare by decreasing reproduction and fur quality. In the majority of mink, the infection is subclinical and the diagnosis must be confirmed by serology or polymerase chain reaction (PCR). Increased knowledge based on a systematically description of clinical signs, pathology and histopathology might be a tool to reduce the risk of infection from subclinically infected mink to AMDV free herds. The aim of this study was to give a histopathological description of the progression of a chronic experimental infection with a currently circulating Danish strain of AMDV, Saeby/DEN/799.1/05. These results were compared with the pathogenesis of previously published AMDV stains.
resultsThis experimental AMDV infection resulted in only decreased appetite and soft or discolored feces, primarily within the first 8 weeks after AMDV inoculation. Gross pathology revealed few and inconsistent findings mainly associated with the liver, spleen and kidneys. The majority of the AMDV inoculated wild type mink (n = 41) developed various histopathological changes consistent with AMDV infection in one or more organs: infiltrations of mononuclear cells in liver, kidney and brain, reduced density of lymphocytes and increased numbers of plasma cells in lymph nodes and spleen. Natural infection, as occurred in the sentinel sapphire mink (four of six mink), progressed similar to the experimentally inoculated mink.
conclusionsExperimental AMDV inoculation mainly resulted in subclinical infection with unspecific clinical signs and gross pathology, and more consistent histopathology appearing at any time after AMDV inoculation during the 24 weeks of observation. Thus, the observed histopathology substantiates AMDV infection and no correlation to time of inoculation was found. This confirms that diagnosing AMDV infection requires serology and/or PCR and the Saeby/DEN/799.1/05 AMDV strain results in histopathology consistent with other AMDV strains.
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