ArticleIEEE transactions on bio-medical engineering2017
A Novel Quantitative 500-MHz Acoustic Microscopy System for Ophthalmologic Tissues.
Article in IEEE transactions on bio-medical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- A systematic review of ultrasound-mediated drug delivery to the eye and critical insights to facilitate a timely path to the clinic.Theranostics · 2023Pooled it
- Enhancing 3-D Radio Frequency Data in Quantitative Acoustic Microscopy Using Quantum-Driven Prior at 250 MHz and 500 MHz.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Article
- Pressure estimation of ultra-high frequency ultrasound using gas vesicles.The Journal of the Acoustical Society of America · 2024Article
- Biomechanical changes occur in myopic choroidal stroma and mirror those in the adjacent sclera.Communications engineering · 2024Article
- A Quantum Denoising-Based Resolution Enhancement Framework for 250-MHz and 500-MHz Quantitative Acoustic Microscopy.IEEE transactions on computational imaging · 2024Article
- Ultrahigh Frequency Ultrasonic Transducers (150MHz) Based on Silicon Lenses.Micromachines · 2023Article
- Advanced Topics in Quantitative Acoustic Microscopy.Advances in experimental medicine and biology · 2023Article
- High-Frequency Ultrasound Activation of Perfluorocarbon Nanodroplets for Treatment of Glaucoma.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Regional changes in the elastic properties of myopic Guinea pig sclera.Experimental eye research · 2019Article
- Ultrahigh Frequency Ultrasonic Transducers Design with Low Noise Amplifier Integrated Circuit.Micromachines · 2018Article
- Improved High-Frequency Ultrasound Corneal Biometric Accuracy by Micrometer-Resolution Acoustic-Property Maps of the Cornea.Translational vision science & technology · 2018Article
- Material Properties of Human Ocular Tissue at 7-µm Resolution.Ultrasonic imaging · 2017Article
- Regular chondrocyte spacing is a potential cause for coherent ultrasound backscatter in human articular cartilage.The Journal of the Acoustical Society of America · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThis paper describes development of a novel 500-MHz scanning acoustic microscope (SAM) for assessing the mechanical properties of ocular tissues at fine resolution. The mechanical properties of some ocular tissues, such as lamina cribrosa (LC) in the optic nerve head, are believed to play a pivotal role in eye pathogenesis.
methodsA novel etching technology was used to fabricate silicon-based lens for a 500-MHz transducer. The transducer was tested in a custom-designed scanning system on human eyes. Two-dimensional (2-D) maps of bulk modulus (K) and mass density (ρ) were derived using improved versions of current state-of-the-art signal processing approaches.
resultsThe transducer employed a lens radius of 125 μm and had a center frequency of 479 MHz with a -6-dB bandwidth of 264 MHz and a lateral resolution of 4 μm. The LC, Bruch's membrane (BM) at the interface of the retina and choroid, and Bowman's layer (BL) at the interface of the corneal epithelium and stroma, were successfully imaged and resolved. Analysis of the 2-D parameter maps revealed average values of LC, BM, and BL with KLC = 2.81 ±0.17; GPa, KBM = 2.89 ±0.18; GPa, KBL = 2.6 ±0.09 ; GPa, ρ LC = 0.96 ±0.03 g/cm SIGNIFICANCE: This novel SAM was shown to be capable of measuring mechanical properties of soft biological tissues at microscopic resolution; it is currently the only system that allows simultaneous measurement of K, ρ, and attenuation in large lateral scales (field area >9 mm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.