ArticleNature communications2016
Geometrical assembly of ultrastable protein templates for nanomaterials.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Biomimetic Carbon-Based Nanomaterials: From Design Strategies to Next-Generation Biosensing and Theranostic Applications.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Automatic design and optimization of MRI-based neurochemical sensors via reinforcement learning.Discover nano · 2025Article
- Coupling of Spectrin Repeat Modules for the Assembly of Nanorods and Presentation of Protein Domains.ACS nano · 2024Article
- Metallization of Targeted Protein Assemblies in Cell-Derived Extracellular Matrix by Antibody-Guided Biotemplating.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- A versatile multimodal chromatography strategy to rapidly purify protein nanostructures assembled in cell lysates.Journal of nanobiotechnology · 2023Article
- Review
- Engineering mono- and multi-valent inhibitors on a modular scaffold.Chemical science · 2021Article
- Synthesis and applications of anisotropic nanoparticles with precisely defined dimensions.Nature reviews. Chemistry · 2021Review
- Structural Determination of a Filamentous Chaperone to Fabricate Electronically Conductive Metalloprotein Nanowires.ACS nano · 2020Article
- Modular repeat protein sculpting using rigid helical junctions.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Bottom-up synthesis of protein-based nanomaterials from engineered β-solenoid proteins.PloS one · 2020Article
- Self-Assembly of Tail Tube Protein of Bacteriophage vB_EcoS_NBD2 into Extremely Long Polytubes inViruses · 2019Article
- Engineering bioorthogonal protein-polymer hybrid hydrogel as a functional protein immobilization platform.Chemical communications (Cambridge, England) · 2019Article
- The Robust Self-Assembling Tubular Nanostructures Formed by gp053 from Phage vB_EcoM_FV3.Viruses · 2019Article
- Biotechnology of extremely thermophilic archaea.FEMS microbiology reviews · 2018Review
- Protein-Mediated Biotemplating on the Nanoscale.Biomimetics (Basel, Switzerland) · 2017Review
- Protein Calligraphy: A New Concept Begins To Take Shape.ACS central science · 2016Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fabrication of nanoscale devices requires architectural templates on which to position functional molecules in complex arrangements. Protein scaffolds are particularly promising templates for nanomaterials due to inherent molecular recognition and self-assembly capabilities combined with genetically encoded functionalities. However, difficulties in engineering protein quaternary structure into stable and well-ordered shapes have hampered progress. Here we report the development of an ultrastable biomolecular construction kit for the assembly of filamentous proteins into geometrically defined templates of controllable size and symmetry. The strategy combines redesign of protein-protein interaction specificity with the creation of tunable connector proteins that govern the assembly and projection angles of the filaments. The functionality of these nanoarchitectures is illustrated by incorporation of nanoparticles at specific locations and orientations to create hybrid materials such as conductive nanowires. These new structural components facilitate the manufacturing of nanomaterials with diverse shapes and functional properties over a wide range of processing conditions.
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