Evidence map›Paper›PMID 27249540›Full record

ArticleJournal of cellular physiology2017

Non-Metabolic Role of PKM2 in Regulation of the HIV-1 LTR.

Satarupa Sen, Satish L Deshmane, Rafal Kaminski, Shohreh Amini, Prasun K Datta

Open access · greenAbstract read
In one paragraph

Article in Journal of cellular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Satarupa SenDepartment of Neuroscience, Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Satish L DeshmaneDepartment of Neuroscience, Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Rafal KaminskiDepartment of Neuroscience, Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Shohreh AminiDepartment of Neuroscience, Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Prasun K DattaDepartment of Neuroscience, Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Temple University · USUniversity of the Sciences · US

Funding

Viral Gene Editing and Bioinformatics Core for Institution # 269291P30MH092177 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI Ilker Kudret Sariyer · 2011 to 2026
$24.9M
Project 3 Dysregulation of metabolic communication of oligodendrocytes and neurons by cocaine and TatP01DA037830 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI KHALILI, KAMEL · 2015 to 2019
$7.4M
Role of epigenetics in glutamate transporter EAAT2regulation in neuroaidsR01DA033213 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI DATTA, PRASUN K · 2011 to 2015
$1.5M
NIDA NIH HHS P01 DA037830NIDA NIH HHS R01 DA033213NIMH NIH HHS P30 MH092177
6 · The paper itself

Abstract

Identification of cellular proteins, in addition to already known transcription factors such as NF-κB, Sp1, C-EBPβ, NFAT, ATF/CREB, and LEF-1, which interact with the HIV-1 LTR, is critical in understanding the mechanism of HIV-1 replication in monocytes/macrophages. Our studies demonstrate upregulation of pyruvate kinase isoform M2 (PKM2) expression during HIV-1

Indexed as

Binding SitesCarrier ProteinsCell NucleusHIV-1HIV Long Terminal RepeatHumansMacrophagesMembrane ProteinsModels, BiologicalMonocytesPromoter Regions, GeneticProtein BindingProtein MultimerizationProtein SubunitsProtein TransportSequence DeletionCarrier ProteinsMembrane ProteinsProtein SubunitsTetradecanoylphorbol AcetateThyroid Hormone-Binding ProteinsThyroid HormonesTranscription Factor RelA

Identifiers

PMID27249540
PMCPMC5714288
OpenAlexW2413757804

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.