Observational studyTherapeutic hypothermia and temperature management2016
Concordance of Brain and Core Temperature in Comatose Patients After Cardiac Arrest.
Observational study in Therapeutic hypothermia and temperature management, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The Association Between Brain Temperature and Neurological Outcome in Out-of-Hospital Cardiac Arrest Patients Who Received Targeted Temperature Management at 33 °C.Reviews in cardiovascular medicine · 2025Article
- Temperature control after cardiac arrest.Resuscitation · 2023Review
- Non-invasive Brain Temperature Measurement in Acute Ischemic Stroke.Frontiers in neurology · 2022Review
- Targeted temperature management and early neuro-prognostication after cardiac arrest.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Review
- European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care.Intensive care medicine · 2021Article
- Brain temperature regulation in poor-grade subarachnoid hemorrhage patients - A multimodal neuromonitoring study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- State-of-the-art considerations in post-arrest care.Journal of the American College of Emergency Physicians open · 2020Review
- Comparison of temperature measurements in esophagus and urinary bladder in comatose patients after cardiac arrest undergoing mild therapeutic hypothermia.Cardiology journal · 2020Observational
- Precise Control of Target Temperature Using NTherapeutic hypothermia and temperature management · 2018Article
- Prediction of brain tissue temperature using near-infrared spectroscopy.Neurophotonics · 2017Article
- Is Esophageal Temperature Better to Estimate Brain Temperature during Target Temperature Management in a Porcine Model of Cardiopulmonary Resuscitation?BioMed research international · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Comatose patients after cardiac arrest should receive active targeted temperature management (TTM), with a goal core temperature of 32-36°C for at least 24 hours. Small variations in brain temperature may confer or mitigate a substantial degree of neuroprotection, which may be lost at temperatures near 37°C. The purpose of this study was to define the relationship between brain and core temperature after cardiac arrest through direct, simultaneous measurement of both. We placed intracranial monitors in a series of consecutive patients hospitalized for cardiac arrest at a single tertiary care facility within 12 hours of return of spontaneous circulation to guide postcardiac arrest care. We compared the absolute difference between brain and core (esophageal or rectal) temperature measurements every hour for the duration of intracranial monitoring and tested for a lag between brain and core temperature using the average square difference method. Overall, 11 patients underwent simultaneous brain and core temperature monitoring for a total of 906 hours of data (Median 95; IQR: 15-118 hours per subject). On average, brain temperature was 0.34C° (95% confidence interval [CI] 0.31-0.37) higher than core temperature. In 7% of observations, brain temperature exceeded the measured core temperature ≥1°C. Brain temperature lagged behind core temperature by 0.45 hours (95% CI = -0.27-1.27 hours). Brain temperature averages 0.34°C higher than core temperature after cardiac arrest, and is more than 1°C higher than core temperature 7% of the time. This phenomenon must be considered when carrying out TTM to a goal core temperature of <36°C.
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