ArticlePLoS neglected tropical diseases2016
Worldwide Phylogenetic Distributions and Population Dynamics of the Genus Histoplasma.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
89 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.
- Histoplasmosis in patients living with HIV in Europe: review of literature.Frontiers in microbiology · 2024Pooled it
- Pulmonary Histoplasmosis, Taiwan, 1997-2024.Emerging infectious diseases · 2026Article
- Genome dynamics and chromosome structural variations in Histoplasma ohiense, a fungal pathogen of humans.G3 (Bethesda, Md.) · 2026Article
- A potential histoplasmosis pathogenesis mechanism mediated by a lectin of Histoplasma capsulatum with affinity to β-galactose, favoring intravascular hemagglutination.PLoS neglected tropical diseases · 2026Article
- Disseminated histoplasmosis diagnosed by mNGS in a middle-aged immunocompetent patient: a case report and literature review.BMC infectious diseases · 2026Review
- MappingApplied and environmental microbiology · 2025Article
- Genomic epidemiology ofmBio · 2025Article
- Histoplasma capsulatum in wild mammals from Ecuador.PLoS neglected tropical diseases · 2025Article
- Disseminated Histoplasmosis in Persons Living with HIV, France and Overseas Territories,1992-2021.Emerging infectious diseases · 2025Article
- Practical Guidance for Clinical Microbiology Laboratories: Antibody and antigen detection methods for dimorphic fungal infections.Clinical microbiology reviews · 2025Review
- High Genetic Diversity of Histoplasma in the Amazon Basin, 2006-2017.Emerging infectious diseases · 2025Article
- Potential predictive value of phylogenetic novelties in clinical fungi, illustrated byIMA fungus · 2025Article
- Emerging Human Health Problems Caused by Pathogenic and Immuno-activating Fungi.Current topics in microbiology and immunology · 2025Review
- New antifungal strategies and drug development against WHO critical priority fungal pathogens.Frontiers in cellular and infection microbiology · 2025Review
- High prevalence ofFrontiers in veterinary science · 2025Article
- Tracing histoplasmosis genomic epidemiology and species occurrence across the USA.Emerging microbes & infections · 2024Article
- Genotypic diversity, virulence, and molecular genetic tools inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Article
- Molecular detection ofEpidemiology and infection · 2024Article
- Validation of a real-time polymerase chain reaction for the detection and quantification of the nucleic acid ofMicrobiology spectrum · 2024Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 5 countries.
Funding
Abstract
backgroundHistoplasma capsulatum comprises a worldwide complex of saprobiotic fungi mainly found in nitrogen/phosphate (often bird guano) enriched soils. The microconidia of Histoplasma species may be inhaled by mammalian hosts, and is followed by a rapid conversion to yeast that can persist in host tissues causing histoplasmosis, a deep pulmonary/systemic mycosis. Histoplasma capsulatum sensu lato is a complex of at least eight clades geographically distributed as follows: Australia, Netherlands, Eurasia, North American classes 1 and 2 (NAm 1 and NAm 2), Latin American groups A and B (LAm A and LAm B) and Africa. With the exception of the Eurasian cluster, those clades are considered phylogenetic species. METHODOLOGY/PRINCIPAL
findingsIncreased Histoplasma sampling (n = 234) resulted in the revision of the phylogenetic distribution and population structure using 1,563 aligned nucleotides from four protein-coding regions. The LAm B clade appears to be divided into at least two highly supported clades, which are geographically restricted to either Colombia/Argentina or Brazil respectively. Moreover, a complex population genetic structure was identified within LAm A clade supporting multiple monophylogenetic species, which could be driven by rapid host or environmental adaptation (~0.5 MYA). We found two divergent clades, which include Latin American isolates (newly named as LAm A1 and LAm A2), harboring a cryptic cluster in association with bats. CONCLUSIONS/SIGNIFICANCE: At least six new phylogenetic species are proposed in the Histoplasma species complex supported by different phylogenetic and population genetics methods, comprising LAm A1, LAm A2, LAm B1, LAm B2, RJ and BAC-1 phylogenetic species. The genetic isolation of Histoplasma could be a result of differential dispersion potential of naturally infected bats and other mammals. In addition, the present study guides isolate selection for future population genomics and genome wide association studies in this important pathogen complex.
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