Evidence map›Paper›PMID 27248117›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2016

A Miniaturized Hemoretractometer for Blood Clot Retraction Testing.

Zida Li, Xiang Li, Brendan McCracken, Yue Shao, Kevin Ward, Jianping Fu

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Blood clot contraction: Mechanisms, pathophysiology, and disease.Research and practice in thrombosis and haemostasis · 2023
    Article
  4. Article
  5. Ultrasound-Guided Intravascular Sonothrombolysis With a Dual Mode Ultrasound Catheter: In Vitro Study.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zida LiDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Xiang LiDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Brendan McCrackenDepartment of Emergency Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Yue ShaoDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Kevin WardDepartment of Emergency Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Jianping FuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
University of Michigan–Ann Arbor · USMichigan Medicine · US

Funding

Microfluidic Functional Immunophenotyping of Pediatric Patients Following CardiopR01HL119542 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CORNELL, TIMOTHY T, FU, JIANPING · 2014 to 2017
$2.7M
NHLBI NIH HHS R01 HL119542
6 · The paper itself

Abstract

Blood coagulation is a critical hemostatic process that must be properly regulated to maintain a delicate balance between bleeding and clotting. Disorders of blood coagulation can expose patients to the risk of either bleeding disorders or thrombotic diseases. Coagulation diagnostics using whole blood is very promising for assessing the complexity of the coagulation system and for global measurements of hemostasis. Despite the clinic values that existing whole blood coagulation tests have demonstrated, these systems have significant limitations that diminish their potential for point-of-care applications. Here, recent advancements in device miniaturization using functional soft materials are leveraged to develop a miniaturized clot retraction force assay device termed mHemoRetractoMeter (mHRM). The mHRM is capable of precise measurements of dynamic clot retraction forces in real time using minute amounts of whole blood. To further demonstrate the clinical utility of the mHRM, systematic studies are conducted using the mHRM to examine the effects of assay temperature, treatments of clotting agents, and pro- and anti-coagulant drugs on clot retraction force developments of whole blood samples. The mHRM's low fabrication cost, small size, and consumption of only minute amounts of blood samples make the technology promising as a point-of-care tool for future coagulation monitoring.

Indexed as

Blood CoagulationBlood Coagulation TestsClot RetractionHemostasisHumansPoint-of-Care Systemsblood coagulationclot retractionminiaturizationpoint-of-care testing

Identifiers

PMID27248117
PMCPMC4980575
OpenAlexW2468065543

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.