ArticleJournal of diabetes research2016
Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes.
Article in Journal of diabetes research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- Sex-dependent and compartment-specific macrophage accumulation associates with glomerular injury in BTBR ob/ob mice.Pflugers Archiv : European journal of physiology · 2026Article
- Sex-specific modulation of gut microbiota by empagliflozin contributes to renoprotection in diabetic kidney disease mice.Frontiers in microbiology · 2026Article
- Renal Status in Newly Diagnosed Patients with Diabetes Mellitus: A Descriptive Study in Primary Care and Opportunities for Improving Management.Journal of clinical medicine · 2025Article
- AI-Assisted identification of sex-specific patterns in diabetic retinopathy using retinal fundus images.PloS one · 2025Article
- Association of Kidney Function With 10-Year Risk of Atherosclerotic Cardiovascular Disease, Cardiovascular Disease and Its Risk Factors Among Women With Type 2 Diabetes Mellitus.International journal of women's health · 2025Article
- Kidney function trajectories, associated factors, and outcomes in multiethnic Asian patients with type 2 diabetes.Journal of diabetes · 2024Article
- Article
- Impact of Gender on Chronic Complications in Participants With Type 2 Diabetes: Evidence From a Cross-Sectional Study.Endocrinology, diabetes & metabolism · 2024Article
- Sex differences in type 2 diabetes.Diabetologia · 2023Review
- Electrocardiogram abnormalities and renal impairment in patients with type 2 diabetes mellitus: A healthcare facilities-based cross-sectional study in Dang district of Nepal.Journal of diabetes investigation · 2023Article
- Sex differences in risk factors for end-stage kidney disease and death in type 2 diabetes: A retrospective cohort study.Journal of diabetes · 2023Observational
- Serum VEGF as a predictive marker of glycemic control and diabetic nephropathy in Chinese older adults with type 2 diabetes mellitus.Frontiers in endocrinology · 2023Article
- Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational Study.Journal of diabetes research · 2022Observational
- Renal function decline in older men and women with advanced chronic kidney disease-results from the EQUAL study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021Article
- Sexual dimorphism in the progression of type 2 diabetic kidney disease in T2DN rats.Physiological genomics · 2021Article
- Gender Differences in Diabetic Kidney Disease: Focus on Hormonal, Genetic and Clinical Factors.International journal of molecular sciences · 2021Review
- Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: The Maastricht Study.Cardiovascular diabetology · 2021Observational
- Sex-related differences in diabetic kidney disease: A review on the mechanisms and potential therapeutic implications.Journal of diabetes and its complications · 2021Review
- Incidence of Diabetic Nephropathy and Its Predictors among Type 2 Diabetes Mellitus Patients at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.Journal of nutrition and metabolism · 2021Article
- Prevalence and incidence of microvascular and macrovascular complications over 15 years among patients with incident type 2 diabetes.BMJ open diabetes research & care · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims. We aimed to investigate the sex differences in the renal function decline among patients with type 2 diabetic mellitus (T2DM), focusing on the differences in the risk factors at early stage of renal dysfunction. Methods. A clinic-based retrospective longitudinal study (follow-up duration: 8.1 ± 1.4 years) was conducted to assess the sex differences in the annual estimated glomerular filtration rate (eGFR) change in 344 (247 male and 97 female) Japanese T2DM patients. The sex differences in the risk factors of annual eGFR decline were subjected to linear regression analyses. Results. The mean annual eGFR change was -3.5 ± 2.7%/year in females and -2.0 ± 2.2%/year in males (P < 0.001). Baseline retinopathy and proteinuria were significantly associated with a larger eGFR decline, irrespective of sex, while HbA1c and LDL-cholesterol levels were significantly associated with an eGFR decline in females only. Interactive effects were observed between sex and the HbA1c, LDL-cholesterol, retinopathy, or proteinuria levels on the annual eGFR decline. Conclusions. The increased susceptibility to poor metabolic control seemed to contribute to a higher risk of renal dysfunction in females with T2DM. Our study highlights the importance of aggressive therapeutic intervention to improve metabolic profiles at early stage, especially in females.
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