ArticleAvicenna journal of phytomedicine
Effect of Nigella sativa on reproductive system in experimental menopause rat model.
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Effect ofNarra J · 2025Trial
- Trial
- The effects of nigella sativa on anthropometric and biochemical indices in postmenopausal women with metabolic syndrome.Endocrine · 2020Trial
- Cedrol Improved Liver and Kidney Injuries in Lipopolysaccharide-Exposed Rats.Advanced biomedical research · 2025Article
- Antimicrobial Properties and Therapeutic Potential of Bioactive Compounds inMolecules (Basel, Switzerland) · 2024Review
- Evaluation of the effect ofHealth science reports · 2024Article
- Enhancement of Female Rat Fertility via Ethanolic Extract fromMolecules (Basel, Switzerland) · 2024Article
- Article
- The Efficacy ofJournal of caring sciences · 2023Article
- Promoting action of vitamin E and black seed oil on reproductive hormones and organ histoarchitecture of Swiss albino mice.Veterinary medicine and science · 2022Article
- Efficacy of nanomicelle curcumin,Food science & nutrition · 2022Article
- Female infertility and herbal medicine: An overview of the new findings.Food science & nutrition · 2021Review
- Therapeutic perspective of thymoquinone: A mechanistic treatise.Food science & nutrition · 2021Review
- Investigating the effect ofAvicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMenopause is the condition when regular menstrual periods cease and may be accompanied by psychological and physical symptoms. The purpose of current study was to determine Nigella sativa effects on reproductive system in experimental menopause animal models. MATERIALS AND
methodsA series of experiments was conducted to investigate the effects of different dosages of N. sativa (first experiment), various extracts of N. sativa (second experiment) and some of its ingredients (third experiment) on selected menopausal parameters of ovariectomized (OVX) rats. Forty different OVX rats were equally divided into 5 groups and administered with one of the following treatments for 21 days: conjugated equine estrogen (positive control), distilled water or olive oil (negative control), treatment groups (N. sativa300, 600 and 1200 mg/kg in the first experiment), (300mg/kg methanol, hexane and SFE extracts of N. sativa in the second experiment) and (linoleic acid 50 mg/kg, gamma linolenic acid 10mg/kg, and thymoquinone 15mg/kg in the third experiment).
resultsThe results demonstrated that N.sativa exert estrogenic effect were exhibited through uterotrophic assay and vaginal cell cornification as well as blood estrogen level. Furthermore, low dose N. sativa, methanol extract and linoleic acid had prominent estrogenic like effects which were significantly different from those of control group (p<0.05) in different experiments.
conclusionThe finding indicated the probable beneficial role for N. sativa in the treatment of postmenopausal symptoms and possibility of using N. sativa as an alternative to hormone replacement therapy (HRT) for post menopause in human.
Indexed as
Identifiers
27247926PMC4884222W2186842273What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.