ArticleAvicenna journal of phytomedicine
Attenuation of morphine tolerance and dependence by thymoquinone in mice.
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The cannabinoid CBNeuropharmacology · 2025Article
- Therapeutic Potential of Black Seed and Opium Poppy Oils in Mitigating Morphine Withdrawal Syndrome in an Animal Model.Addiction & health · 2025Article
- Protective effects of pistachio hydroalcoholic extract on morphine-induced analgesic tolerance and dependence: investigating the impact of oxidative stress.Research in pharmaceutical sciences · 2024Article
- Cannabinoid CBBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024Article
- Disulfiram Produces Potent Anxiolytic-Like Effects Without Benzodiazepine Anxiolytics-Related Adverse Effects in Mice.Frontiers in pharmacology · 2022Article
- Clinical and Imaging Study of Repetitive Transcranial Magnetic Stimulation in the Treatment of Morphine Dependence Through mGluR5/TDP43/NR2B Pathway.Journal of healthcare engineering · 2021Article
- Plants with Anti-Addictive Potential.Advances in experimental medicine and biology · 2021Article
- Effect of Essential Oil of Zhumeria majdae on Morphine Tolerance and Dependence in Mice.Chinese journal of integrative medicine · 2020Article
- Thymoquinone: FromIranian journal of basic medical sciences · 2020Review
- The Attenuating Effect of Curcumin on Morphine Dependence in Rats: The Involvement of Spinal Microglial Cells and Inflammatory Cytokines.Iranian journal of pharmaceutical research : IJPR · 2019Article
- Role of L-arginine/NO/cGMP/KIranian journal of basic medical sciences · 2018Article
- Slowly Signaling G Protein-Biased CBMolecular pharmacology · 2018Article
- Neuropharmacological Potential and Delivery Prospects of Thymoquinone for Neurological Disorders.Oxidative medicine and cellular longevity · 2018Review
- α-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide.Iranian journal of basic medical sciences · 2016Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDependence and tolerance are major restricting factors in the clinical use of opioid analgesics. In the present study, the effects of thymoquinone, the major constituent of Nigella sativa seeds, on morphine dependence and tolerance were investigated in mice. MATERIALS AND
methodsMale adult NMRI mice were made tolerant and dependent by repeated injections of morphine (50, 50, and 75 mg/kg, i.p. on 9 a.m., 1 p.m., and 5 p.m., respectively) during a 3-day administration schedule. The hot-plate test was used to assess tolerance to the analgesic effects of morphine. Naloxone (2 mg/kg, i.p.) was injected to precipitate withdrawal syndrome in order to assess the morphine dependence. To evaluate the effects of thymoquinone on tolerance and dependence to morphine, different single or repeated doses of thymoquinone were administered in mice. Rotarod was used to assess the motor coordination.
resultsAdministration of single or repeated doses of thymoquinone (20 and 40 mg/kg, i.p.) significantly decreased the number of jumps in morphine dependent animals. Repeated administration of thymoquinone (20 and 40 mg/kg, for 3 days) and also single injection of thymoquinone (40 mg/kg, on the fourth day) attenuated tolerance to the analgesic effect of morphine. None of the thymoquinone doses (10, 20, and 40 mg/kg) produced any antinociceptive effects on their own. Motor coordination of animals was impaired by the high dose of thymoquinone (40 mg/kg).
conclusionBased on these results, it can be concluded that thymoquinone prevents the development of tolerance and dependence to morphine.
Indexed as
Identifiers
27247922PMC4884218What OpenQuestion holds
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