ArticleBrain and behavior2016
Exogenous dopamine reduces GABA receptor availability in the human brain.
Article in Brain and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Brain Networks, Neurotransmitters and Psychedelics: Towards a Neurochemistry of Self-Awareness.Current neurology and neuroscience reports · 2024Review
- Precision Medicine Care in ADHD: The Case for Neural Excitation and Inhibition.Brain sciences · 2021Article
- Effects of interactions between variation in dopaminergic genes, traumatic life events, and anomalous self-experiences on psychosis proneness: Results from a cross-sectional study in a nonclinical sample.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- The Molecular Organization of Self-awareness: Paralimbic Dopamine-GABA Interaction.Frontiers in systems neuroscience · 2020Article
- Attenuation of dopamine-induced GABA release in problem gamblers.Brain and behavior · 2019Article
- Test-retest reproducibility of quantitative binding measures of [NeuroImage · 2017Article
- Altered right anterior insular connectivity and loss of associated functions in adolescent chronic fatigue syndrome.PloS one · 2017Article
- Exogenous dopamine reduces GABA receptor availability in the human brain.Brain and behavior · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile it has recently been shown that dopamine release stimulates conscious self-monitoring through the generation of gamma oscillations in medial prefrontal/anterior cingulate cortex, and that the GABAergic system is effective in producing such oscillations, interaction of the two transmitter systems has not been demonstrated in humans. We here hypothesize that dopamine challenge stimulates the GABA system directly in the medial prefrontal/anterior cingulate region in the human brain.
methodsPositron emission tomography (PET) with the GABA receptor α1/α5 subtype ligand [(11)C] Ro15-4513 was used to detect changes in GABA receptor availability after clinical oral doses of levodopa in a double blind controlled study.
resultsWe here provide the first direct evidence for such coupling in the cerebral cortex, in particular in the medial prefrontal anterior cingulate region, by showing that exogenous dopamine decreases [(11)C] Ro15-4513 binding widely in the human brain compatible with a fall in α1 subtype availability in GABA complexes due to increased GABA activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.