ArticleNutrition research and practice2016
Fermentation of purple Jerusalem artichoke extract to improve the α-glucosidase inhibitory effect in vitro and ameliorate blood glucose in db/db mice.
Article in Nutrition research and practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Chemical components and pharmacological action forChinese herbal medicines · 2026Review
- Phytochemical Composition and Mechanistic Pharmacology of Jerusalem Artichoke (Current issues in molecular biology · 2026Review
- Protective effect of short-chain fructo-oligosaccharides from chicory on alcohol-induced injury in GES-1 cells via Keap1/Nrf2 and NLRP3 inflammasome signaling pathways.Frontiers in nutrition · 2024Article
- Characterization ofInternational journal of microbiology · 2024Article
- Fructose-Containing Plant Carbohydrates: Biological Activities and Medical Applications.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2023Article
- Fermentation of Jamaican Cherries Juice UsingMolecules (Basel, Switzerland) · 2021Article
- Defatted Seeds ofFoods (Basel, Switzerland) · 2021Article
- Inactivation of Inulinase and Marination of High-Quality Jerusalem Artichoke (Frontiers in bioengineering and biotechnology · 2020Article
- A Mini Review on Antidiabetic Properties of Fermented Foods.Nutrients · 2018Review
- Xanthium strumarium as an Inhibitor of α-Glucosidase, Protein Tyrosine Phosphatase 1β, Protein Glycation and ABTS⁺ for Diabetic and Its Complication.Molecules (Basel, Switzerland) · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesJerusalem artichoke has inhibitory activity against α-glucosidase and decreases fasting serum glucose levels, which may be related to its fructan content. The biological activity of fructan can be influenced by the degree of polymerization. Thus, in this study, the inhibitory effects of original and fermented purple Jerusalem artichoke (PJA) on α-glucosidase were compared in vitro. Additionally, the anti-diabetes effect of Lactobacillus plantarum-fermented PJA (LJA) was studied in a non-insulin-dependent diabetes mellitus animal model (C57BIKsJ db/db). MATERIALS/
methodsThe water extract of PJA was fermented by L. plantarum, and two strains of Bacillus subtilis to compare their anti-α-glucosidase activities in vitro by α-glucosidase assays. The anti-diabetes effect of LJA was studied in a non-insulin-dependent diabetes mellitus animal model (C57BIKsJ db/db) for seven weeks. During the experiment, food intake, body weight, and fasting blood glucose were measured every week. At the end of the treatment period, several diabetic parameters and the intestinal α-glucosidase activity were measured.
resultsThe LJA showed the highest α-glucosidase inhibitory activity in vitro. In the in vivo study, it resulted in a significantly lower blood glucose concentration than the control. Serum insulin and HDL cholesterol levels were significantly higher and the concentrations of triglycerides, non-esterified fatty acids, and total cholesterol were significant lower in mice treated with LJA after seven weeks. In addition, the intestinal α-glucosidase activity was partially inhibited.
conclusionsThese results suggested that LJA regulates blood glucose and has potential use as a dietary supplement.
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