ReviewWorld journal of stem cells2016
Endometrial mesenchymal stem cells as a cell based therapy for pelvic organ prolapse.
Review in World journal of stem cells, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Vaginal Ulcers Secondary to Stage Iv Uterine Prolapse Treated With L-PRF.Clinical case reports · 2026Article
- AI-driven discovery of novel extracellular matrix biomarkers in pelvic organ prolapse.PLoS computational biology · 2025Article
- Isolation and characterization mesenchymal stem cells from red panda (Conservation physiology · 2022Article
- Cell-based endometrial regeneration: current status and future perspectives.Cell and tissue research · 2021Review
- Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction.Nanomaterials (Basel, Switzerland) · 2020Review
- Towards uterus tissue engineering: a comparative study of sheep uterus decellularisation.Molecular human reproduction · 2020Article
- Joint report on terminology for surgical procedures to treat pelvic organ prolapse.International urogynecology journal · 2020Article
- Article
- Electrospun Nanofiber Meshes With Endometrial MSCs Modulate Foreign Body Response by Increased Angiogenesis, Matrix Synthesis, and Anti-Inflammatory Gene Expression in Mice: Implication in Pelvic Floor.Frontiers in pharmacology · 2020Article
- Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application.Frontiers in cell and developmental biology · 2020Review
- Anti-inflammatory effect of adipose-derived stem cells in the treatment of pelvic organ prolapse.The Journal of international medical research · 2019Article
- Mesenchymal stem cell-based bioengineered constructs: foreign body response, cross-talk with macrophages and impact of biomaterial design strategies for pelvic floor disorders.Interface focus · 2019Review
- Management of Occult Urinary Incontinence with Prolapse Surgery.Current urology reports · 2019Review
- Stem cells on regenerative and reproductive science in domestic animals.Veterinary research communications · 2019Review
- Systemically transplanted mesenchymal stem cells induce vascular-like structure formation in a rat model of vaginal injury.PloS one · 2019Article
- Recent advances in pelvic floor repair.F1000Research · 2019Review
- Quiescent Human Mesenchymal Stem Cells Are More Resistant to Heat Stress than Cycling Cells.Stem cells international · 2018Article
- Isolation and characterization of equine endometrial mesenchymal stromal cells.Stem cell research & therapy · 2017Article
- Vaginal wall weakness in parous ewes: a potential preclinical model of pelvic organ prolapse.International urogynecology journal · 2017Article
- Ovine multiparity is associated with diminished vaginal muscularis, increased elastic fibres and vaginal wall weakness: implication for pelvic organ prolapse.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pelvic organ prolapse (POP) occurs when the pelvic organs (bladder, bowel or uterus) herniate into the vagina, causing incontinence, voiding, bowel and sexual dysfunction, negatively impacting upon a woman's quality of life. POP affects 25% of all women and results from childbirth injury. For 19% of all women, surgical reconstructive surgery is required for treatment, often augmented with surgical mesh. The surgical treatment fails in up to 30% of cases or results in adverse effects, such as pain and mesh erosion into the bladder, bowel or vagina. Due to these complications the Food and Drug Administration cautioned against the use of vaginal mesh and several major brands have been recently been withdrawn from market. In this review we will discuss new cell-based approaches being developed for the treatment of POP. Several cell types have been investigated in animal models, including a new source of mesenchymal stem/stromal cells (MSC) derived from human endometrium. The unique characteristics of endometrial MSC, methods for their isolation and purification and steps towards their development for good manufacturing practice production will be described. Animal models that could be used to examine the potential for this approach will also be discussed as will a rodent model showing promise in developing an endometrial MSC-based therapy for POP. The development of a preclinical large animal model for assessing tissue engineering constructs for treating POP will also be mentioned.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.