ArticlePsychiatry investigation2016
Salivary Nitric Oxide, a Biomarker for Stress and Anxiety?
Article in Psychiatry investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Evaluation of Anxiolytic, Amnesic, and Psychomotor Effects of Nitrous Oxide Inhalation Sedation: AnInternational journal of clinical pediatric dentistry · 2025Article
- An Impact of Psychological Stress on the Interplay between Salivary Oxidative Stress and the Classic Psychological Stress-Related Parameters.Oxidative medicine and cellular longevity · 2021Article
- Metabolomic Biomarkers in Anxiety Disorders.International journal of molecular sciences · 2020Review
- The relationship between salivary alpha-amylase, nitric oxide, pain and anxiety-induced stress in patients during dental treatment.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
objectiveTo investigate if salivary nitrate correlates to the daily psychological stress and anxiety in a group of human subjects.
methodsThe convenient sample recruitment method was employed; data from seventy three subjects were analyzed. The Perceived Stress Scale (PSS) and Hamilton Anxiety Rating Scale (HAM-A) inventories were used to determine stress and anxiety scores respectively. Salivary nitric oxide was measured through nitrate (NOx) levels using the Griess reaction method.
resultsAlthough stress and anxiety were correlated. No significant correlation exists between salivary nitrate and daily psychological stress and anxiety in the study's participants.
conclusionWhile all previous studies focused NOx levels in acute stress models. This is the first study to investigate the correlation between salivary nitrates and daily psychological stress and anxiety. Although stress and anxiety were correlated, there is no correlation between salivary nitrates and daily psychological stress and anxiety. Further studies are required to investigate this correlation using other biological samples such as plasma.
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