ArticleKorean journal of ophthalmology : KJO2016
Oxidative Stress Levels in Aqueous Humor from High Myopic Patients.
Article in Korean journal of ophthalmology : KJO, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- 650 nm red light enhances aldehyde dehydrogenase 3A1 expression in retina pigment epithelial cells in vitro and in vivo.Indian journal of ophthalmology · 2026Article
- Clinical characteristics and risk factors of ocular hypertension: a case-control study.BMC ophthalmology · 2025Article
- Biomarkers: Promising Tools Towards the Diagnosis, Prognosis, and Treatment of Myopia.Journal of clinical medicine · 2024Review
- Reduced retinol (vitamin A) and α-tocopherol (vitamin E) blood levels and increased myeloperoxidase (MPO) activity in children with high myopia.Scientific reports · 2024Article
- The effect of age on aqueous humor of humans with high myopia.Molecular vision · 2024Article
- Next-Generation Sequencing Screening of 43 Families with Non-Syndromic Early-Onset High Myopia: A Clinical and Genetic Study.International journal of molecular sciences · 2022Article
- High Myopia and the Complement System: Factor H in Myopic Maculopathy.Journal of clinical medicine · 2021Article
- Lipid Peroxidation in Subretinal Fluid: Some Light on the Prognosis Factors.Biomolecules · 2021Article
- Importance of the Use of Oxidative Stress Biomarkers and Inflammatory Profile in Aqueous and Vitreous Humor in Diabetic Retinopathy.Antioxidants (Basel, Switzerland) · 2020Review
- Morphologic and biochemical changes in the retina and sclera induced by form deprivation high myopia in guinea pigs.BMC ophthalmology · 2020Article
- Imbalance Between Oxidative Stress and Growth Factors in Human High Myopia.Frontiers in physiology · 2020Article
- The expression of cytokines in aqueous humor of high myopic patients with cataracts.Molecular vision · 2020Article
- Update on Myopia Risk Factors and Microenvironmental Changes.Journal of ophthalmology · 2019Review
- Olfactomedin-like 2 A and B (OLFML2A and OLFML2B) expression profile in primates (human and baboon).Biological research · 2016Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare oxidative stress status in the aqueous humor of highly myopic eyes and control eyes.
methodsAqueous humor samples were collected from 15 highly myopic eyes (high myopia group) and 23 cataractous eyes (control group) during cataract surgery. Central corneal thickness, corneal endothelial cell density, hexagonality of corneal endothelial cells, and cell area of corneal endothelial cells were measured using specular microscopy. Axial length was measured using ultrasound biometry. 8-Hydroxydeoxyguanosine (8-OHdG) and malondialdehyde levels were measured using enzyme-linked immunosorbent assay.
results8-OHdG level was lower in the aqueous humor of myopic patients than in that of control group (p = 0.014) and was positively correlated with central corneal thickness and negatively correlated with axial length (r = 0.511, p = 0.02; r = -0.382, p < 0.001). There was no correlation between 8-OHdG level and corneal endothelial cell density, hexagonality, or cell area. Malondialdehyde level did not show any correlation with any parameters evaluated.
conclusions8-OHdG might be a sensitive biomarker for evaluating oxidative stress status in the eye. Oxidative stress level was lower in the aqueous humor of highly myopic eyes compared to that in control eyes, which indicates lower metabolic activity in these eyes.
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