Trial reportBehavioural neurology2016
The Interactive Relationship between Pain, Psychosis, and Agitation in People with Dementia: Results from a Cluster-Randomised Clinical Trial.
Trial report in Behavioural neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01021696 (The Impact of Pain on Behavioural Disturbances in Patients With Moderate and Severe Dementia. A Cluster Randomized Trial), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Pain on Behavioural Disturbances in Patients With Moderate and Severe Dementia. A Cluster Randomized Trial
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between pain and behavioral and psychological symptoms of dementia (BPSD) in older adults with dementia: a systematic review and meta-analysis.BMC geriatrics · 2025Pooled it
- Algorithm-based pain management for people with dementia in nursing homes.The Cochrane database of systematic reviews · 2022Pooled it
- Trial
- Aggression Prevention Training for Individuals With Dementia and Their Caregivers: A Randomized Controlled Trial.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020Trial
- Staff experiences with implementing a case conferencing care model in nursing homes: a focus group study.BMC health services research · 2019Trial
- Agitation in dementia: Evidence-based consensus recommendations.Journal of the Chinese Medical Association : JCMA · 2026Review
- Substance Use and Incidence of Psychosis Diagnoses Among Gay, Bisexual, and Other Men Who Have Sex with Men Compared with Males from the General Population: A Matched Cohort Study from Metro Vancouver, Canada.Substance use & misuse · 2026Article
- The story of pain in people with dementia: a rationale for digital measures.BMC medicine · 2025Article
- Incidence and factors associated with agitation in patients on mechanical ventilators in Amhara Region, North-West Ethiopia: a multi-center study.Scientific reports · 2025Article
- Pain prevalence, intensity, and association with neuropsychiatric symptoms of dementia in immigrant and non-immigrant aged care residents in Australia.Scientific reports · 2024Article
- Pain prevalence and pain relief in end-of-life care - a national registry study.BMC palliative care · 2024Article
- Are Opioids Agitating? A Data Analysis of Baseline Data from the STAN Study.Journal of Alzheimer's disease reports · 2024Article
- Pharmacological and non-pharmacological prevention and management of delirium in critically ill and palliative patients in the inpatient setting: a review.Frontiers in medicine · 2024Review
- Nursing-sensitive quality indicators for quality improvement in Norwegian nursing homes - a modified Delphi study.BMC health services research · 2023Review
- Pain and quality of life in nursing home residents with dementia after admission - a longitudinal study.BMC health services research · 2023Article
- Emotional and Neuropsychiatric Disorders Associated with Alzheimer's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Prevalence and persistent use of analgesic drugs in older adults receiving domiciliary care at baseline-A longitudinal study.Health science reports · 2021Article
- Pain in Advanced Stages of Dementia: The Perspective of Medical Students.Medicina (Kaunas, Lithuania) · 2019Article
- Pharmacologic Management of Agitation in Patients with Dementia.Current geriatrics reports · 2019Article
- The knowledge and attitudes of general practitioners to the assessment and management of pain in people with dementia.BMC family practice · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Neuropsychiatric symptoms are common in people with dementia, and pain is thought to be an important underlying factor. Pain has previously been associated with agitation, and pain treatment has been shown to ameliorate agitated behaviour. So far, the association between pain and psychosis and the effect of pain treatment on psychotic symptoms is unclear. Furthermore, the impact of opioid treatment on psychosis is not established. Aim. To investigate the efficacy of a stepwise protocol for treating pain (SPTP) on psychosis and agitation measured with the Neuropsychiatric Inventory, Nursing Home version, and to explore the impact of opioid analgesics on psychosis. Method. Secondary analyses are from a cluster-randomised controlled trial including 352 patients with advanced dementia and agitation from 18 nursing homes in Western Norway. The intervention group received pain treatment according to SPTP. Results. Pain was associated with disinhibition (adjusted OR: 1.21, 95% CI: 1.10-1.34) and irritability (adjusted OR: 1.10, 95% CI: 1.01-1.21) at baseline. Pain treatment reduced agitation (p < 0.001, df = 1; 300) and aberrant motor behaviour (p = 0.017, df = 1; 300). Psychosis was reduced in people with at least one symptom at baseline (p = 0.034, df = 1; 135). The use of opioid analgesics did not increase psychotic symptoms. Study Registration. This trial is registered with ClinicalTrials.gov (NCT01021696), Norwegian Medicines Agency, EudraCT (EudraCTnr: 2008-007490-20).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.