Evidence map›Paper›PMID 27247281›Full record

ArticleBMJ (Clinical research ed.)2016

Migraine and risk of cardiovascular disease in women: prospective cohort study.

Tobias Kurth, Anke C Winter, A Heather Eliassen, Rimma Dushkes, Kenneth J Mukamal, Eric B Rimm, Walter C Willett, JoAnn E Manson, Kathryn M Rexrode

Erratum issued Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ (Clinical research ed.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05943457 (Efficacy of Vitamin K2 Supplementation in Adult Episodic Migraine), which is not on this map. Cited by 115 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 12 pooled it
29.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05943457 narecruitingnot on this mapstarted 2024, after this paper: background citation

Efficacy of Vitamin K2 Supplementation in Adult Episodic Migraine

TypeinterventionalSponsorSola Aoun Bahous, M.D. Ph.D.Ran2024 to 2026Enrolled160ConditionsMigraine Headache, Arterial Stiffness, Vitamin K DeficiencyArmsVitamin K2 or menaquinone-7, Placebo
3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 12 syntheses or guidelines pooled it, 277 citations in OpenAlex.

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  12. Migraine and the risk of stroke: an updated meta-analysis of prospective cohort studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017
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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Tobias KurthInstitute of Public Health, Charité - Universitätsmedizin, D-10117 Berlin, Germany Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA tobias.kurth@charite.de.
Anke C WinterDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA.
A Heather EliassenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Rimma DushkesInstitute of Public Health, Charité - Universitätsmedizin, D-10117 Berlin, Germany.
Kenneth J MukamalDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Eric B RimmDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Walter C WillettDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
JoAnn E MansonInstitute of Public Health, Charité - Universitätsmedizin, D-10117 Berlin, Germany Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kathryn M RexrodeInstitute of Public Health, Charité - Universitätsmedizin, D-10117 Berlin, Germany.
Brigham and Women's Hospital · USCharité - Universitätsmedizin Berlin · DEHarvard University · USWashington University in St. Louis · US

Funding

Risk Factors for Ischemic Stroke in WomenR01HL088521 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REXRODE, KATHRYN M · 2008 to 2025
$9.9M
NHLBI NIH HHS R01 HL088521
6 · The paper itself

Abstract

objectiveTo evaluate the association between migraine and incident cardiovascular disease and cardiovascular mortality in women.

designProspective cohort study among Nurses' Health Study II participants, with follow-up from 1989 and through June 2011.

settingCohort of female nurses in United States.

participants115 541 women aged 25-42 years at baseline and free of angina and cardiovascular disease. Cumulative follow-up rates were more than 90%.

main outcome measuresThe primary outcome of the study was major cardiovascular disease, a combined endpoint of myocardial infarction, stroke, or fatal cardiovascular disease. Secondary outcome measures included individual endpoints of myocardial infarction, stroke, angina/coronary revascularization procedures, and cardiovascular mortality.

results17 531 (15.2%) women reported a physician's diagnosis of migraine. Over 20 years of follow-up, 1329 major cardiovascular disease events occurred and 223 women died from cardiovascular disease. After adjustment for potential confounding factors, migraine was associated with an increased risk for major cardiovascular disease (hazard ratio 1.50, 95% confidence interval 1.33 to 1.69), myocardial infarction (1.39, 1.18 to 1.64), stroke (1.62, 1.37 to 1.92), and angina/coronary revascularization procedures (1.73, 1.29 to 2.32), compared with women without migraine. Furthermore, migraine was associated with a significantly increased risk for cardiovascular disease mortality (hazard ratio 1.37, 1.02 to 1.83). Associations were similar across subgroups of women, including by age (<50/≥50), smoking status (current/past/never), hypertension (yes/no), postmenopausal hormone therapy (current/not current), and oral contraceptive use (current/not current).

conclusionsResults of this large, prospective cohort study in women with more than 20 years of follow-up indicate a consistent link between migraine and cardiovascular disease events, including cardiovascular mortality. Women with migraine should be evaluated for their vascular risk. Future targeted research is warranted to identify preventive strategies to reduce the risk of future cardiovascular disease among patients with migraine.

Indexed as

Cardiovascular DiseasesMigraine DisordersAdultCausalityCohort StudiesFemaleHumansMiddle AgedMyocardial RevascularizationProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsStatistics as TopicUnited States

Identifiers

PMID27247281
PMCPMC4887613
OpenAlexW2416895451

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.