ArticleeLife2016
Constitutive auxin response in Physcomitrella reveals complex interactions between Aux/IAA and ARF proteins.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed, 164 citations in OpenAlex.
- Mutational analyses of an instability domain reveal its conserved role in the regulation of class-B ARF levels inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Biogenesis and downstream effects of 3',5' and 2',3' cAMP isomers in plants.Science advances · 2026Article
- Diversification of functional requirements for proteolysis of auxin response factors.Nature communications · 2026Article
- The tasiR-ARF pathway in plants: origin, functions, and interplay of miR-390, tasiRNAs and ARF3.Plant biology (Stuttgart, Germany) · 2026Review
- Genome-wide unraveling of theFrontiers in plant science · 2026Article
- Essential developmental processes in Physcomitrium patens require distinct levels of total activity provided by functionally redundant PpROP GTPases.The New phytologist · 2025Article
- Hormonomics profiles revealed the mechanisms of cold stratification in breaking the dormancy during seed germination and emergence process of Polygonatum sibiricum Red.Plant signaling & behavior · 2025Article
- The role of auxin-mediated gene activation in the bryophyte, Physcomitrium patens.Journal of experimental botany · 2025Article
- Expression analyses of sweet cherry AUX/IAAs and involvements of PavAUX/IAA9/11 in regulating fruitlet abscission.Plant cell reports · 2025Article
- O-Fucosyltransferase SPINDLY attenuates auxin-induced fruit growth by inhibiting ARF6/8-coactivator mediator complex interaction in Arabidopsis.Nature communications · 2025Article
- Genome-Wide Identification of the ARF Gene Family in Safflower (International journal of molecular sciences · 2025Article
- Comparative mutant analyses reveal a novel mechanism of ARF regulation in land plants.Nature plants · 2025Article
- Conserved roles of ETT and ARF4 in gynoecium development in Brassicaceae with distinct fruit shapes.Development (Cambridge, England) · 2025Article
- Quantitative imaging reveals the role of MpARF proteasomal degradation during gemma germination.Plant communications · 2024Article
- Protein degradation in auxin response.The Plant cell · 2024Review
- Phytohormone profiling in an evolutionary framework.Nature communications · 2024Article
- An auxin research odyssey: 1989-2023.The Plant cell · 2024Review
- Divergence of trafficking and polarization mechanisms for PIN auxin transporters during land plant evolution.Plant communications · 2024Article
- Enigmatic role of auxin response factors in plant growth and stress tolerance.Frontiers in plant science · 2024Review
- Game of thrones among AUXIN RESPONSE FACTORs-over 30 years of MONOPTEROS research.Journal of experimental botany · 2023Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The coordinated action of the auxin-sensitive Aux/IAA transcriptional repressors and ARF transcription factors produces complex gene-regulatory networks in plants. Despite their importance, our knowledge of these two protein families is largely based on analysis of stabilized forms of the Aux/IAAs, and studies of a subgroup of ARFs that function as transcriptional activators. To understand how auxin regulates gene expression we generated a Physcomitrella patens line that completely lacks Aux/IAAs. Loss of the repressors causes massive changes in transcription with misregulation of over a third of the annotated genes. Further, we find that the aux/iaa mutant is blind to auxin indicating that auxin regulation of transcription occurs exclusively through Aux/IAA function. We used the aux/iaa mutant as a simplified platform for studies of ARF function and demonstrate that repressing ARFs regulate auxin-induced genes and fine-tune their expression. Further the repressing ARFs coordinate gene induction jointly with activating ARFs and the Aux/IAAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.