Toxoplasma Retromer Is Here to Stay.

Olivia L McGovern, Vern B Carruthers

Abstract readComment

In one paragraph

Article in Trends in parasitology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Life cycle stages, specific organelles and invasion mechanisms ofParasitology · 2020
Review
Updated Insight into the Physiological and Pathological Roles of the Retromer Complex.International journal of molecular sciences · 2017
Review
A Critical Role for Toxoplasma gondii Vacuolar Protein Sorting VPS9 in Secretory Organelle Biogenesis and Host Infection.Scientific reports · 2016
Article

4 · The record

Corrections and comments

Comment on
Unconventional endosome-like compartment and retromer complex in Toxoplasma gondii govern parasite integrity and host infection.2016

5 · Who and what money

Authors and funding

2 authors.

Olivia L McGovernDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-5620, USA.

Vern B CarruthersDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-5620, USA. Electronic address: vcarruth@umich.edu.

Funding

Parasite autophagy as a key survival mechanism for the AIDS-associated pathogen Toxoplasma gondiiR01AI120607 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 2016 to 2025

$4.0M

NIAID NIH HHS R01 AI120607

6 · The paper itself

Abstract

How the protozoan pathogen Toxoplasma gondii and related parasites shuttle proteins through their intricate system of endomembranous compartments remains unclear. Sangaré et al. show that the Toxoplasma retromer complex is essential for parasite viability through its role in protein targeting to multiple locales and its interactions with newly identified partners.

Indexed as

AnimalsHost-Parasite InteractionsMultiprotein ComplexesOrganellesProtein TransportProtozoan Proteinsrab11 GTP-Binding Proteinsrab GTP-Binding ProteinsToxoplasmaMultiprotein ComplexesProtozoan Proteinsrab11 GTP-Binding Proteinsrab GTP-Binding Proteinsmembraneparasiteproteintargetingtrafficking

Identifiers

PMID27247246

DOI10.1016/j.pt.2016.05.007

PMCPMC5048501

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.