Evidence map›Paper›PMID 27247158›Full record

ArticleAfrican journal of primary health care & family medicine2016

Profile and anticoagulation outcomes of patients on warfarin therapy in an urban hospital in Cape Town, South Africa.

Babatunde O Sonuga, Derek A Hellenberg, Clint S Cupido, Cilia Jaeger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in African journal of primary health care & family medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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  14. Atrial fibrillation in low- and middle-income countries: a narrative review.European heart journal supplements : journal of the European Society of Cardiology · 2020
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  17. Anticoagulation Control, Outcomes, and Associated Factors in Patients with Atrial Fibrillation Receiving Warfarin at Tertiary Care Hospital in Ethiopia.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Babatunde O SonugaDivision of Family Medicine, School of Public Health and Family Medicine, University of Cape Town. tunde.sonuga@gmail.com.
Derek A Hellenberg
Clint S Cupido
Cilia Jaeger
University of Cape Town · ZAVictoria Hospital · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWarfarin is the most frequently used oral anticoagulant worldwide and it is the oral anticoagulant of choice in South Africa for reducing thrombosis-related morbidity and mortality. However, the safety and efficacy of warfarin therapy depends mainly on careful monitoring and maintenance of the international normalised ratio (INR) within an optimal therapeutic range.

aimThe aim of this study was to describe the profile and the anticoagulation outcomes of patients on warfarin therapy in a major warfarin clinic in the Western Cape Province of South Africa.

settingVictoria Hospital - a district hospital in Cape Town.

methodsA cross sectional review of clinical records of patients on warfarin therapy who attended the INR clinic from 01 January 2014 to 30 June 2014 was done. Data analysis was done with STATA to generate appropriate descriptive data.

resultsOur study showed that atrial fibrillation (AF) was the commonest indication for warfarin use in this study and hypertension was the commonest comorbidity among these patients. Only 48.5% achieved target therapeutic range; 51.5% were out-of-range. There was a significant association between alcohol consumption and poor anticoagulation outcomes (p-value < 0.022). Anticoagulation outcomes were better among the older age groups, male patients and in those with AF. The prevalence of thrombotic events while on warfarin treatment was 2.2%, while prevalence of haemorrhagic events was 14%. Most of the patients with bleeding events were on concurrent use of warfarin and other medications with potential drug interactions.

conclusionIn our study, patients who achieved target therapeutic control were less than the acceptable 60%.

Indexed as

AdolescentAdultAgedAged, 80 and overAnticoagulantsCross-Sectional StudiesFemaleHospitals, DistrictHospitals, UrbanHumansInternational Normalized RatioMaleMiddle AgedRetrospective StudiesRisk FactorsSouth AfricaAnticoagulantsWarfarinanticoagulation outcomesOral anticoagulantpercentage INR within target therapeutic range (%ITTR)therapeutic controlTime in therapeutic range (TIR).

Identifiers

PMID27247158
PMCPMC4913441
OpenAlexW2410566890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.